对这些核酸序列做计算分析,数据显示环境核酸中存在丰富的细菌非编码RNA(ncRNA),它们的大小与大型核糖酶相似,并且具有复杂的生物学结构。 令Ronald R. Breaker研究组特别感兴趣的是,在环境RNA的筛选过程中发现了两种新的RNA,它们分别被称为GOLLD和HEARO,据Ronald R. Breaker介绍这两种非编码RNA(ncRNA)是迄今所发现的...
Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells Brice Laffleur Junghyun Lim Uttiya Basu Nature Genetics(2021) Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation ...
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Cryo-EM data processing Cryo-EM datasets were processed using cryoSPARC v3.2.16 The raw movies were imported into cryoSPARC, motion corrected using MotionCor244 and the contrast transfer function (CTF) was determined using CTFFIND4,45 followed by manual curation of the micrographs. For the 224 ...
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The HLBs are known to harbor large amounts of histone pre-mRNA and histone 3'-end processing components [128], whereas the Cajal bodies contain small nuclear ribonucleoproteins (snRNPs) and are suggested to generate and recycle these proteins [129,130]. The de novo formation of both these ...
The HLBs are known to harbor large amounts of histone pre-mRNA and histone 3'-end processing components [128], whereas the Cajal bodies contain small nuclear ribonucleoproteins (snRNPs) and are suggested to generate and recycle these proteins [129,130]. The de novo formation of both these ...