可促进NCR+ILC3分化及相关细胞因子分泌,抑制LTi ILC3分化,调节LTi ILC3/NCR+ILC3细胞免疫平衡,进一步印证了NCR+ILC3受丁酸诱导,与共生微生物互为调控,保护肠道黏膜屏障的机制.结论五味苦参肠溶胶囊治疗DHAS-UC具有充分的临床依据,该药通过直接作用于肠道黏膜层及菌群,上调代谢产物丁酸含量,从而促进NCR+ILC3的分化...
Results NCR þ ILC3 accumulate in NSCLC tissues. We have previously shown that a CD3negCD56 þ NKp44 þ cell population selectively infiltrates NSCLC, whereas it is virtually undetectable in normal lung tissues42. In addition, NCR þ cells are mainly localized in the tumour stroma, in ...
Teunissen MB, Munneke JM, Bernink JH et al. Composition of innate lym- phoid cell subsets in the human skin: enrichment of NCR ILC3 in lesional skin and blood of psoriasis patients. J Invest Dermatol 2014; 134:2351-60.Teunissen, M. B., Munneke, J. M., Bernink, J. H., Spuls,...
固有淋巴细胞是(ILCs)一群新近发现的隶属于固有免疫的免疫细胞,它们具有优于获得性免疫的反应迅速的特点.现在的研究普遍将固有淋巴细胞分为三类:Group1 ILC,ILC2和ILC3.虽然近期的研究已经证明ILCs具有明显的组织分布特点且能迅速应对多种病原的感染,但是ILCs对于胞内致病菌感染的保护性作用和机制还鲜有研究.在本课题...
Group 1 ILCs Isolation, Culture, and Identification of Natural Killer Cells ITIM/ITAM Immunoreceptors and Related Molecules Lymphoid Lineage Markers Natural Cytotoxicity Receptors (NCRs) and Ligands Natural Killer T (NKT) Cells NCR+ILC3 NCR-ILC3...
Product Datasheets Product Datasheet COA SDS Related Research Areas Group 1 ILCs ITIM/ITAM Immunoreceptors and Related Molecules Natural Cytotoxicity Receptors (NCRs) and Ligands Natural Killer T (NKT) Cells NCR+ILC3 NCR-ILC3
Group 3 NCR+ Innate Lymphoid Cells accumulate in human lung cancer Tertiary lymphoid structures (TLS) are a common finding in non-small-cell lung (NSCL) cancers and are predictors of favorable clinical outcome. Here, we show that NCR+ Innate-Lymphoid-Cells (ILC)3s are present in the...
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NKp46 is expressed by activated and resting natural killer (NK) cells, innate lymphoid cell (ILC) 1, and a small population of T lymphocytes (1). NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCRs) (2)....
(ILC) 1, and a small population of T lymphocytes (1). NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCRs) (2). The NKp46 and NKp30 receptors play a major role in triggering some of the key lytic ...