However, the effect of downregulation of LeY expression on cell proliferation in HER2-overexpressing cells remains unknown. FUT1 encodes 伪1,2-fucosyltransferase, a key enzyme for LeY synthesis. We knocked down FUT1 by short interfering RNA (siRNA) in four HER2-overexpressing human cancer cell ...
Furthermore, the HercepTest, a semi-quantitative immunohistochemistry assay, was performed to determine the expression of HER2 protein, a transmembrane tyrosine kinase receptor that plays a key role in the development and progression of gastric cancer cells [22]. Images showed a strong reduction of...