NCI-H716 cells as a model for endocrine differentiation in colorectal cancer. Virchows Archiv B: Cell Pathol 1992;62:311-20.De Bruine AP, Dinjens WNM, Pijls MMJ, Van der Linden EPM, Rousch MJM, Moerkerk PT, De Goeij AFPM, Bosman FT(1992) NCI-H716 cells as a model for endocrine ...
NCI-H716 cells were one of several colorectal cancer cell lines originally described in 1987 (Park et al.1987). This particular cell line was developed from cells harvested in ascites fluid of a 33-year old Caucasian male with colorectal cancer. Interestingly, of the 14 cell lines described i...
We also demonstrated that CK can affect the RhoA/ROCK/YAP pathway, which is downstream of transforming growth factor β1 (TGFβ1), by maintaining the capacity of intestinal differentiation. In addition, this effect was mediated by regulating F/G-actin dynamics. These results provide not only ...
After several years of being used as model of tumour/endocrine differentiation, Reimer et al. demonstrated both expression and regulated secretion of glucagon-like peptide-1 (GLP-1) by these cells (Reimer et al. 2001). In that study, NCI-H716 cells were found to secrete high levels of ...