The crude extract library of an authentic collection of TCM herbs described here has been developed to facilitate systematic biological evaluation of the therapeutic potential of traditional Chinese medicines. It is a new addition to the NCI Natural Product Repository, freely available to investigators ...
Medium and high through-put screens interrogate pure compound libraries and uniquely focus on screening the vast library of extracts, over 160,000 in number, in the NCI's Natural Product Repository. This repository provides an unmatched and relatively unexploited source of chemical diversity for lead...
a natural product isolated from the marine sponge Halichondira okadai. Eribulin mesylate is a white powder which is freely soluble in water, methanol, ethanol, 1-octanol, benzyl alcohol, dichloromethane, dimethylsulfoxide, N-methylpyrrolidone and ethyl acetate. It is soluble ...
Specifically, several natural product clusters were associated with SLFN11 gene expression, suggesting that potential action of these compounds may involve DNA damage. The associations between gene expression or genome alterations of functionally relevant genes with the response of cancer cells to natural ...
Determination of pyrethroids and their degradation productds in indoor air and on surfaces by HRGC‐ECD and HRGC‐MS(NCI)Capillary gas chromatography, HRGCMass spectrometry, MSPyrethroidsDegradation productsAir and surface samples taken following indoor applications of natural pyrethrins and pyrethroids have...
Determination of pyrethroids and their degradation productds in indoor air and on surfaces by HRGC-ECD and HRGC-MS(NCI)Capillary gas chromatography, HRGCMass spectrometry, MSPyrethroidsDegradation productsAir and surface samples taken following indoor applications of natural pyrethrins and pyrethroids have ...
Benzo[a]carbazole-1,4-dione 14a was one of 6 hits out of 2000 in the NCI library to inhibit Plasmodium kinesin-5 from both human and malaria vivax [83]. Compounds 14a and 14d–f were amongst 35 hits out of 1597 compounds in the NCI Diversity SET III screen with >50% inhibitory ...