ECOG-ACRIN)癌症研究组负责全面协调MATCH试验项目,全美加入国家临床试验网(National Clinical Trials Network,NCTN)和NCI社区肿瘤研究计划(NCI Community Oncology Research Program,NCORP)的2400个医疗点和研究所都已受邀参与。
美国肿瘤临床学会(American Society of Clinical Oncology)研究论坛理事会主席Michael Thompson是一名肿瘤学家,他表示:需要从与以往不同的收集过程中减少毒性,并试图得到最佳的组织。 此外,个性化疗法就像MATCH trial试验要求:组织样本不仅仅是权威诊断的,并且是可以重复的,且有多重药物选择来组织肿瘤进一步发展的。 马萨...
3. Flaherty KT, Gray RJ, Chen AP, et al: Molecular landscape and actionable alterations in a genomically guided cancer clinical trial: National Cancer Institute Molecular Analysis for Therapy Choice (NCI-MATCH). J Clin Oncol 38:3883-38...
美国肿瘤临床学会(American Society of Clinical Oncology)研究论坛理事会主席Michael Thompson是一名肿瘤学家,他表示:需要从与以往不同的收集过程中减少毒性,并试图得到最佳的组织。 此外,个性化疗法就像MATCH trial试验要求:组织样本不仅仅是权威诊断的,并且是可以重复的,且有多重药物选择来组织肿瘤进一步发展的。 马萨...
在Ion Torrent 平台上使用 NCI-MATCH 试验检测试剂盒—性能验证结果 NCI-MATCH 试验检测试剂盒* 基于 143-基因 Oncomine Comprehensive检测试剂盒。在性能验证研究中,NCI-MATCH 试验检测试剂盒在 455 次测序运行中表现出了高重现性、高灵敏度和特异性。 在...
Clinical trials are the best sources of such data, but audits to assess validity are rare, compromising future machine learning efforts. We reviewed AEs reported on the National Cancer Institute Molecular Analysis for Therapy Choice (NCI-MATCH) EAY-131 Arm Z1D. Patients matched to Arm Z1D ...
In the present NCI-MATCH subprotocol EAY131-Y trial, we analyzed the clinical outcomes and safety of capivasertib in patients with an AKT1 E17K-mutated tumor. We aimed to assess the objective response rate (ORR) among these patients. Methods This nonrandomized trial was approved by the ...
MolecularAnalysis for Therapy Choice (NCI-MATCH/EAY-131), recently prof i led inthe Journal of Clinical Oncology, is thelargest accruing therapeutic trial toaddress ways that actionable geneticalterations can be identif i ed and tar-geted-treatment can be delivered inunderexplored tumor types. The...
While this subprotocol did not meet the primary end point for ORR in this heavily pre-treated diverse patient population, clinical activity was seen in salivary gland tumors warranting further study in this tumor type in dedicated trials. 展开 关键词: HER2-amplified T-DM1 NCI-MATCH NGS ...
且自2017年起,NIH进一步启动了儿童肿瘤相关的MATCH项目——NCI-Children’s Oncology Group Pediatric MATCH Trial (NCI-COG Pediatric MATCH),该项目针对1-21岁的儿童和青少年,患有难治性或复发性实体瘤、非霍奇金淋巴瘤或组织细胞疾病,在美国COG 接受治疗的患者纳入该多中心Ⅱ期临床试验。从石蜡包埋的肿瘤样本中提...