狼疮致病变异体NCF1-H90在小鼠和系统性红斑狼疮患者中减少巨噬细胞胞葬作用,增强Tfh2反应并促进自身抗体产生和肾损伤。 目的:该研究团队之前确定了中性粒细胞胞质因子1(NCF1,吞噬细胞烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶2复合物的...
efferocytosisWe previously identified a hypomorphic variant, p.Arg90His (p.R90H) of neutrophil cytosolic factor 1 (NCF1,a regulatory subunit of phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 complex), as an putative causal variant for systemic lupus erythematosus (SLE), and...
Role of Nephrotoxic Serum-Driven Ferroptosis in Ncf1-p.R90H KI Female Micedoi:10.1681/ASN.2024k2b36cd8Mariia StefanenkoMedical University of South Carolina, Charleston, South Carolina, United States;Lei WangMedical University of South Carolina, Charleston, South Carolina, United States;Mykhailo ...