The SLC4A4 gene expresses three major NBCe1 isoforms: NBCe1-A (expressed in renal proximal tubular epithelial cells), NBCe1-B (expressed in a variety of epithelial and excitable cells), and NBCe1-C (expressed in neurons and glial cells). Aside from distribution differences, each isoform has...
生理学报 Acta Physiologica Sinica , December 25, 2012, 64(6): 729–740 729 综 述 + − Na /HCO3 共转运体NBCe1 的生理及病理学作用 1,3 2,3 1,3,* 刘颖 ,卢群伟 ,陈历明 1 2 3 华中科技大学生命科学与技术学院 生物物理学及分子生理学系; 遗传与发育生物学系; 分子生物物理学教育部重点实...
The electrogenic Na+-HCO3鈥 cotransporter NBCe1 encoded by SLC4A4 gene plays essential roles in the regulation of intracellular/extracellular pH. Three NBCe1 variants are thought to mediate distinct physiological roles with different modes of transport stoichiometry. Homozygous inactivating mutations in ...
The kidney specific form of the electrogenic sodium bicarbonate cotransporter NBCe1-A (SLC4A4 gene) plays a key role in bicarbonate reabsorption in the kidney proximal tubule. Mutations in the SLC4A4 gene cause severe proximal renal tubular acidosis (pRTA). The current therapy of pRTA is ...
via the electrogenic Na+/HCO3−cotransporter NBCe1-A1. NBCe1-A in PT cells is also a major contributor to the reabsorption of ~80% of the HCO3−filtered at the glomerulus. NBCe1-A is one of three major products of theSLC4A4gene; the others, NBCe1-B and NBCe1-C, are expressed...
Genetics遗传学:meiosis, sexual and asexual reproduction, Mendelian inheritance, DNA, genes and chromosomes, protein synthesis, mutation, genetic disorders in humans, gene expression and manipulation Evolution进化:historical context for evolutionary theory, evi...
Recent single cell transcriptomics studies of human pancreatic islets have identified Slc4a4 (encoding an electrogenic Na + -nHCO 3 cotransporter, NBCe1) as a gene repressed in healthy non-diabetic β-cells, but expressed in human T2DM β-cells. However the role of Slc4a4 /NBCe1 in ...
Thus far, NBCs are found in the SLC4 gene family, which also includes Na+-independent anion exchangers. Of the ten SLC4 genes, five genes are Na+ bicarbonate cotransport systems: 2 electrogenic transporters, NBCe1 and 2 (SLC4A4 and A5); 2 electroneutral, NBCn1 and 2 (SLC4A7 and A8...
and caused only limited changes in gene expression patterns,such as those for electrical excitability.However,following ischemia and reperfusion,KO heart sections exhibited significantly fewer apoptotic nuclei than WT sections.CONCLUSION These studies indicate that cardiac-specific loss of NBCe1 does not ...
We examined membrane trafficking of NBCe1-A and NBCe1-B variants of the electrogenic Na+-HCO3- cotransporter (NBCe1) encoded by the SLC4A4 gene, using confocal fluorescent microscopy in rat parotid acinar cells (ParC5 and ParC10). We showed that yellow fluorescent protein (YFP)-tagged NBC...