Nature Reviews Drug Discovery volume 12, pages 447–464 (2013)Cite this article 28k Accesses 931 Citations 12 Altmetric Metrics details Key Points Nucleoside and nucleotide analogues are largely used in the treatment of cancer and viral infections. A large number of novel compounds continue to be...
Nature Reviews Drug Discovery12,433–446 (2013)Cite this article 24kAccesses 419Citations 15Altmetric Metrics ACorrigendumto this article was published on 29 November 2013 This article has beenupdated Key Points The human genome is pervasively transcribed. Most RNA transcripts represent non-coding RNA...
12, 135–142 (2015). CAS PubMed Google Scholar Boon, R. A. et al. MicroRNA-34a regulates cardiac ageing and function. Nature 495, 107–110 (2013). CAS PubMed Google Scholar Bang, C. et al. Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hyp...
Life-omics Research Division, Institute for Open and Transdisciplinary Research Initiative, Osaka University, Osaka, Japan Yu Miyamoto, Junichi Kikuta, Kentaro Fujii, Yutaka Uchida, Erika Yamashita & Masaru Ishii Laboratory of Bioimaging and Drug Discovery, National Institutes of Biomedical Innovation, Hea...
Review Article Published: 12 February 2016 Coronaviruses — drug discovery and therapeutic options Alimuddin Zumla, Jasper F. W. Chan, Esam I. Azhar, David S. C. Hui & Kwok-Yung Yuen Nature Reviews Drug Discovery volume 15, pages 327–347 (2016)Cite this article 72k Accesses 227 ...
Nature Reviews Drug Discovery volume 15, pages 620–638 (2016)Cite this article 10k Accesses 230 Citations 99 Altmetric Metrics details Key Points Fibroblasts have central roles in cardiac homeostasis and in the pathogenic remodelling that occurs during myocardial ischaemia, hypertension and heart fa...
Plenge, R. M., Scolnick, E. M. & Altshuler, D. Validating therapeutic targets through human genetics.Nat. Rev. Drug Discov.12, 581–594 (2013). ArticleCASPubMedGoogle Scholar Nelson, M. R. et al. The support of human genetic evidence for approved drug indications.Nat. Genet.47, 856...
The HIV epidemic has devastated millions of people globally, with approximately 40 million deaths since its start. The availability of antiretroviral therapy (ART) has transformed the prognosis of millions of individuals infected with HIV such that a dia
Nature Reviews Drug Discovery (2021) Novel Targeted Therapeutics in Acute Myeloid Leukemia: an Embarrassment of Riches Nicole R. Grieselhuber Alice S. Mims Current Hematologic Malignancy Reports (2021) Structural modification of 4, 5-dihydro-[1, 2, 4] triazolo [4, 3-f] pteridine derivatives...
Nature Reviews Drug Discovery volume 16, pages 35–52 (2017)Cite this article 13k Accesses 354 Citations 57 Altmetric Metrics details Key Points Mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells, actively contribute to the formation of the tumour microenvironment, wherein they...