Ferumoxytol (Fer), an aqueous iron oxide nanoparticle formulation approved by the Food and Drug Administration (FDA) for systemic treatment of iron deficiency, has shown both efficacy and specificity against cariogenic biofilms when used topically, through selective pathogen binding and acidic pH-activat...
the Near East and Mediterranean North Africa, providing evidence for human exploitation of the honeybee from at least the seventh millennium BC12. However, little is known of its importance in other areas globally, for example, in the subsistence ...
such as pseudouridine, N1-methylpseudouridine or other nucleoside analogues23. Because all native mRNAs include modified nucleosides, the immune system has evolved to recognize unmodified single-stranded RNA, which is a hallmark of viral infection. Specifically, unmodified mRNA is recognized bypattern r...
In addition, the chemical composition of many calcium orthophosphates includes hydrogen, either as part of an acidic orthophosphate anion (for example, HPO42- or H2PO4-), hydroxide (for example, Ca10(PO4)6(OH)2) and/or incorporated water (for example, CaHPO4·2H2O). Diverse combinations...