A wasting or weakening of the body owing to chronic illness or cancer. Nanobody An engineered single-domain antibody. Rights and permissions Reprints and permissions About this article Cite this article Jones, S.A., Jenkins, B.J. Recent insights into targeting the IL-6 cytokine family in infl...
Down syndrome (DS), the genetic condition caused by trisomy 21, is characterized by variable cognitive impairment, immune dysregulation, dysmorphogenesis and increased prevalence of diverse co-occurring conditions. The mechanisms by which trisomy 21 causes these effects remain largely unknown. We demonstr...
In addition, podoplanin on the tumor cell surface can cause platelet aggregation by engaging CLEC-2 receptors [164]; this interaction enhances platelet TGF-β release to induce epithelial-mesenchymal transition (EMT) in tumor cells. This drives the tumor toward a more migratory phenotype, tumor ...
The frequency of cases of relapse of illness might have been higher if most patients had not been provided empiric antibiotic therapy during their first episode of fever. The fever associated with B. miyamotoi infection generally lasts less than a week, even without antibiotic therapy, while other...
The master should have a questionnaire, that should include any type of illness. A list of all medications and why they are prescribed. Here is why I’m going over this, if you are not asking all these questions and you hurt someone, guess what ? Knowing all the answers can not only...
Integrating physical activity into mental health services for persons with serious mental illness. Psychiatr. Serv. 2005, 56, 324–331. [CrossRef] [PubMed] 15. Johansson, M.; Hartig, T.; Staats, H. Psychological benefits of walking: Moderation by company and outdoor environment. Appl. ...
We conclude that pulmonary epithelial cells undergoing EMT, rather than immune cells, are likely responsible for the 3p21.31-associated risk. Since the 3p21.31 effect is conferred by a gain-of-function, LZTFL1 may represent a therapeutic target....
7. Endpoints were vaginal bleeding, severe abdominal distension, and signs of severe illness, such as dehydration, hunching, jaundice, ruffled fur, signs of infection, or non-responsiveness. Sample sizes within each genotype were chosen based on the proportions of animals with vaginal bleeding ...
Molecular dissection of CRC primary tumors and their matched liver metastases reveals critical role of immune microenvironment, EMT and angiogenesis in cancer metastasis ArticleOpen access01 July 2020 Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung aden...
(EMT)” signatures were significantly induced in the KRAS associated genes (Supplementary Fig.1cand Supplementary Data2). The top-scored lncRNAs induced by KRAS, with a fold change above 3, wereLinc02575andHIF1A-As2(Fig.1c). WhileHIF1A-as2has been previously reported to have an oncogenic ...