此外,研究人员发现KDM4A-AS1通过抑制AR/AR-Vs降解来增强CRPC对恩杂鲁胺的耐药性;通过将靶向KDM4A-AS1的反义寡核苷酸药物(ASO-KDM4A-AS1,10mg/kg)腹腔注射到异种移植小鼠体内,结果发现显著降低了对恩杂鲁胺耐药的肿瘤的生长。 Fig4. 靶向KDM4A-AS1的ASO药物可恢复恩杂鲁胺耐药性 总之,本研究结果表明KDM4A-AS...
BACKGROUND: It is unclear wheather the association between C-reactive protein (CRP) and incident coronary events is free from bias and confounding. Individuals homozygous for a +1444C>T polymorphism in the CRP gene have higher circulating concentrations of CRP. Since the distribution of this polymo...
Recent studies have demonstrated that constitutive expression of AR splice variants lacking the ligand binding domain significantly contributes to the development and progression of CRPC [80]. Among these, the most studied AR splice variant, AR-V7 or AR3, activates AR-regulated genes in the ...
To date, SWI/SNF alterations have not been studied in the context of advanced PCa. In this study, we show that SWI/SNF composition is altered in the setting of CRPC-NE and that in contrast to many of the above-cited tumor types, SWI/SNF can have tumor-promoting functions in PCa. We...
It was found that 7-deoxy penicillin-CRP complex and 6-amino penicilloyl CRP conjugate binds to the antibody with energies stronger than that with the 14 C-penicilloyl CRP. All the other analogue conjugates are much weaker in interfering with the binding of the penicilloyl CRP with the ...
This study examined the relation between high-sensitivity C-reactive protein (CRP), exercise-induced myocardial ischemia, and exercise tolerance in 288 sta... Jeryes Shehadeh and Basil S Lewis and Giora Weisz and Miriam David and Tamar Ashkenazi and David A Halon - 《American Journal of Cardiolo...
Introduction C-reactive protein (CRP) is an acute-phase reactant with an increasing number of clinical functions. Studies in recent years have identified s... TV Johnson,A Abbasi,VA Master - 《Molecular Diagnosis & Therapy》 被引量: 32发表: 2013年 SMALL DISCOVERIES CAN HAVE GREAT CONSEQUENCES...
CRP, Creactive protein; RF, rheumatoid factor. Mechanisms involved in initiation and progression of rheumatoid arthritis a | Post-translational modifications, such as by citrullination or carbamylation, in the mucosa can create neo-epitopes that can be recognized by the adaptive immune system. b | ...
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such as the second-generation AR antagonist enzalutamide (ENZ), leads to castration-resistant (CRPC) or treatment-induced neuroendocrine prostate cancer (NEPC)1. The most frequently characterized mechanisms of PC or CRPC resistance to ARSIs, ADT, or both revolve around the restoration of AR signal...