To target cytotoxins, we hypothesized that relying solely on β-strand pairing interactions might not adequately prevent cytotoxin insertion into membranes because of the critical role of their three-finger loops in membrane interaction and disruption47,48,49,50(Fig.1b). Instead, we focused on bind...
Microglia are important players in surveillance and repair of the brain. Implanting an electrode into the cortex activates microglia, produces an inflammatory cascade, triggers the foreign body response, and opens the blood-brain barrier. These changes can impede intracortical brain-computer interfaces ...
Previously,R(τ/μ) has been measured at the Large Electron–Positron Collider (LEP), yielding a combined value of 1.070 ± 0.026 (ref.3). The SM expectation ofR(τ/μ) is unity (neglecting very small phase space effects due to the masses of the decay products, ~5 × 10...
The best way to find the "nature" of the critical points of a general function of three or more variables is to first write the "true" second derivative. Not the partials. Just as the "true" first derivative of a function of three variables is a vector, the gradient, [∂f∂x...
I shall attempt to summarize and synthesize the key concepts and drivers that may lead us to extinction, as well as those that may mitigate the specter of extinction and instead lead toward stabilization and perhaps even, an AI utopia. First, the dark side… ...
Furthermore, we find that critical changes, such as plugin configuration updates, are performed shortly before or on the release day. The results of this study enable researchers to study build systems in much more detail. Our approach to extract build changes from Maven that we present in ...
Stationary point of a function is a point where the derivative of a function is equal to zero and can be a minimum, maximum, or a point of inflection
mice per dose were used, and a 100 µl bolus was injected intraperitoneally in the right lower abdominal region; controls received only PBS. The injected mice were observed for the first 2 h and then again at 24 h. LD50values were calculated using the Quest Graph LD50Calculator71....
It has long been proposed that phase-separated compartments can provide a basis for the formation of cellular precursors in prebiotic environments. However, we know very little about the properties of coacervates formed from simple peptides, their compat
The cumulative number of stem cell divisions in a tissue, known as mitotic age, is thought to be a major determinant of cancer-risk. Somatic mutational and DNA methylation (DNAm) clocks are promising tools to molecularly track mitotic age, yet their rela