manipulation and recording experiments, we identify oxytocin neurons in the retrochiasmatic supraoptic nucleus (SOROXT) and oxytocin-receptor-expressing cells in the anterior subdivision of the ventromedial hypothalamus, ventrolateral part (aVMHvlOXTR) as a key circuit motif for defeat-induced social ...
This study reports the generation of an ADAR1 editing-deficient knock-in mouse, showing that A-to-I editing is crucial to prevent spontaneous MDA5 activation. Article CAS PubMed PubMed Central Google Scholar Goodman, R. A., Macbeth, M. R. & Beal, P. A. ADAR proteins: structure and ...
J. Back in the water: the return of the inositol phosphates. Nature Rev. Mol. Cell Biol. 2, 327–338 (2001) Article CAS Google Scholar Macbeth, M. R. et al. Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing. Science 309, 1534–1539 (2005) Article ...
Comparing these two systems for application in GC-rich C. glutamicum (53.8% GC-content for type strain ATCC 13032), the CRISPR/Cas9 system recognizing G-rich protospacer adjacent motif (PAM) sequences should have a wider genome targeting scope than the CRISPR/Cas12a system recognizing T-rich ...
Macbeth, M. R. et al. Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing. Science 309, 1534–1539 (2005) ADS CAS PubMed PubMed Central Google Scholar Losey, H. C., Ruthenburg, A. J. & Verdine, G. L. Crystal structure of Staphylococcus aureus tRNA...
J. Back in the water: the return of the inositol phosphates. Nature Rev. Mol. Cell Biol. 2, 327–338 (2001) Article CAS Google Scholar Macbeth, M. R. et al. Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing. Science 309, 1534–1539 (2005) Article ...
3 PEs are enriched in CpG-rich motifs and are bound by CxxC-domain containing proteins. a, Comparison of the TF motifs enriched in either PEs with a CAP-CGI in <3kb and active enhancers without CAP-CGIs in <3kb. Motif enrichment analyses were performed with Homer82 (left) and AME107...
ultimately leading to greater IKZF1 and CK1α degradation potency when compared to lenalidomide37. Importantly, besides the lenalidomide-like interaction between C7 of the solvent-exposed phthalimide ring and G40 of the β-hairpin loop (degron motif) in the N-lobe of CK1α, compound SJ7095 form...