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performed complete necropsies and histopathology for toxicity experiments. C.L.M. contributed to data analysis. M.J.F. performed docking studies. H.L., V.M.W. and C.R.B. provided conceptualization and supervision. K.P., D.J.S., G.S.T. and C.R.B. wrote the manuscript with ...
Control of the magnet’s position and the piezo was achieved with a multifunction DAQ card (National Instruments), using custom-made data-acquisition software. The molecule of interest (R16-Ig27WT and Ig27WT-R16 in our case) was tethered to a superparamagnetic Dynabeads M-270 streptavidin-...
3). The VirB8 binder made extensive interactions with the helical regions of VirB8 as designed; no native proteins have been identified to bind to this region. The Cα r.m.s.d. over the entire miniprotein binder was 2.54 Å using the VirB8 as the alignment reference, and the ...
Activation of the p53 tumor suppressor triggers a transcriptional program to control cellular response to stress. However, the molecular mechanisms by which p53 controls gene transcription are not completely understood. Here, we uncover the critical role
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