Chun-Bing Chen , Shuen-Iu Hung & Wen-Hung Chung Article 30 December 2024 | Open Access Characterizing mutation-treatment effects using clinico-genomics data of 78,287 patients with 20 types of cancers Using clinico-genomic data from 78,287 cancer patients, this study identifies genomic alt...
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Bacterial chemotaxis requires bidirectional flagellar rotation at different rates. Rotation is driven by a flagellar motor, which is a supercomplex containing multiple rings. Architectural uncertainty regarding the cytoplasmic C-ring, or ‘switch’, limi
Exceptions were made for clinically actionable somatic variants detected below these thresholds. Reference genome The clinical cancer panel and research genomes were aligned to hg19. Automated variant prioritization using an internal website and database...
The development of advanced perovskite emitters has considerably improved the performance of perovskite light-emitting diodes (LEDs). However, the further development of perovskite LEDs requires ideal device electrical properties, which strongly depend o
such as the in silico design of tailor-made molecules and materials or the in-depth understating of supramolecular complexation phenomena, to name a few. In the context of XCAI, two key challenges in achieving explainability can be identified. Firstly, the rapid growth of atomic pairs (≈M2)...
Early patterning of neural crest cells (NCCs) in the craniofacial primordium is important for subsequent development of proper craniofacial structures. However, because of the complexity of the environment of developing tissues, surveying the early speci
Mutations were made in PyMol or Coot89. Coordinates were then fitted using Isolde (116) followed by iterative refinement using Phenix90 real-space refinement. Structure and map analyses were performed using PyMol67, Chimera91, and ChimeraX92. Surface plasmon resonance The SPR binding curves of ...
(57 out of 88) of patients with mutations inCTNNB1were associated with HuMo 1 and made up 47% (57 out of 118) of patients in that cluster (Extended Data Fig.8a,b). Moreover, humans and mice associated with HuMo cluster 1 had immune-cell paucity and a low immune score (Fig.3a,...
Richter transformation (RT) is a paradigmatic evolution of chronic lymphocytic leukemia (CLL) into a very aggressive large B cell lymphoma conferring a dismal prognosis. The mechanisms driving RT remain largely unknown. We characterized the whole genome,