Overexposure to manganese disrupts cellular energy metabolism across species, but the molecular mechanism underlying manganese toxicity remains enigmatic. Here, we report that excess cellular manganese selectively disrupts coenzyme Q (CoQ) biosynthesis,
Considering the key roles of ubiquinol 9 (CoQ9H2) and ubiquinol 10 (CoQ10H2) in the mitochondrial respiratory chain and cellular homeostasis55,56, we measured the levels of CoQ9H2 and CoQ10H2 in equal amounts of mouse brown adipose tissue. The results indicate that, compared to the ...
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(BH4) pathways16. Among of them, FSP1-CoQ10is an independent parallel system that cooperates with the primary glutathione-GPX4 pathway to inhibit ferroptosis. FSP1 is recently identified as a breakthrough owing to its unique ability to suppress ferroptosis by reducing ubiquinone to ubiquinol2,3,...
A co-evolution-based approach predicting the residue–residue contacts in protein–protein interactions, RaptorX-ComplexContact33, was used to identify the TMHs at CIII2CIV interface. The single TMH containing CIV-related proteins (i.e., CcoQ subunit, CcoS and CcoH assembly factors29, and cytc...