Autism spectrum disorder (ASD) is the most common genetic neurodevelopmental disorder, characterized by impaired social communication and restricted, repetitive behaviors1. Headway in understanding ASD pathophysiology has been stymied by tremendous phenotypic heterogeneity and complex genetics across individuals. ...
7,8. Recently developed technologies and analytical methods provide groundbreaking opportunities for both the improved sampling of biodiversity and unravelling how biodiversity is structured at large spatial
). A large majority of such differentially expressed genes (DEGs) encode for the products which regulate signal transduction, several biological processes, cell-to-cell communication, and protein-protein or protein-nucleic acid interaction and hence were predominantly localised to cellular membrane or ...
During the coronavirus disease 2019 (COVID-19) pandemic, a wave of rapid and collaborative drug discovery efforts took place in academia and industry, culminating in several therapeutics being discovered, approved and deployed in a 2-year time frame. This article summarizes the collective experience ...
Communication between organelles is essential for their cellular homeostasis. Neurodegeneration reflects the declining ability of neurons to maintain cellular homeostasis over a lifetime, where the endolysosomal pathway plays a prominent role by reg
and cell–cell communication3,4. Approximately 35% of all food and drug administration (FDA)-approved drugs target GPCRs5,6, stressing their importance for biomedical research and drug development. However, major challenges exist in investigating GPCR signaling. First, several GPCRs have unidentified...
The core board with a field-programmable gate array (FPGA) supports the lower computer in communication with the upper computer and generation of control signals for operations. The TIA&ADC board and each DAC board provide 64 current quantization channels and 64 voltage supply channels, respectively...
Identifying the mechanisms underlying the regulation of immune checkpoint molecules and the therapeutic impact of targeting them in cancer is critical. Here we show that high expression of the immune checkpoint B7-H3 (CD276) and high mTORC1 activity corr
Cell-free microcompartmentalised transcription-translation for the prototyping of synthetic communication networks. Curr. Opin. Biotechnol. 58, 72–80 (2019). Article CAS PubMed PubMed Central Google Scholar Zhang, C., Liu, H., Li, X., Xu, F. & Li, Z. Modularized synthetic biology ...
(Fig.4). Impairment of this cross-cell communication was observed in the aged intestine caused by increased mtDNA mutation burden (Fig.4), implying an important role in small intestine aging. These findings provide insights into the intestinal cell differentiation processes. Upon aging, intestinal ...