Autism spectrum disorder (ASD) is the most common genetic neurodevelopmental disorder, characterized by impaired social communication and restricted, repetitive behaviors1. Headway in understanding ASD pathophysiology has been stymied by tremendous phenotypic heterogeneity and complex genetics across individuals. ...
Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication. Nat. Cell Biol. 21, 9–17 (2019). Article CAS PubMed Google Scholar Piccin, A., Murphy, W. G. & Smith, O. P. Circulating microparticles: pathophysiology and clinical ...
with some campaigns specifically claiming target-to-lead times as low as 1–2 months9,10, or target-to-clinic time under 1 year11. Are these the signs of a major shift in the role that computational approaches have in drug discovery or just another...
, astonishment, helplessness and fear are among the first reactions (Focus Online2019,2021; Kreiszeitung,2019; tz 2021). Notably, human-wolf conflicts in Germany, as elsewhere, emerge when wolves prey on livestock (Fuhr,2014; Bloch & Radinger,2017; Faß,2018; Bellin-Harder,2019; Heurich20...
Recent studies have shown that lysosomal cathepsin B (CTSB), a family member of lysosomal cysteine protease, actively modulates the proteolysis of extracellular matrix components, disruption of intracellular communication, degradation of the basement membrane and alteration of cell-cell interactions, thereby...
Ca2+ overload-induced mitochondrial dysfunction is considered as a major contributing factor in the pathogenesis of alcohol-associated liver disease (ALD). However, the initiating factors that drive mitochondrial Ca2+ accumulation in ALD remain elusive.
and at the allosteric communication network between these regions. However, further work is needed to interrogate the fitness of these mutant enzymes in authentic viral systems using reverse genetics. A similar mutagenesis approach has been successfully applied to predict clinically relevant patterns of ...
Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication. Nat. Cell Biol. 21, 9–17 (2019). Article PubMed CAS Google Scholar Morrison, K. E. et al. Developmental Timing of Trauma in Women Predicts Unique Extracellular Vesicle Proteome ...
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease. To identify additional genetic factors, we analyzed exome sequences in a large cohort of Chinese ALS patients and found a homozygous variant (p.L700P) in PCDHA9 in three unre
(Fig.4). Impairment of this cross-cell communication was observed in the aged intestine caused by increased mtDNA mutation burden (Fig.4), implying an important role in small intestine aging. These findings provide insights into the intestinal cell differentiation processes. Upon aging, intestinal ...