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Several theories have been proposed to describe the formation of black hole seeds in the early Universe and to explain the emergence of very massive black holes observed in the first thousand million years after the Big Bang1,2,3. Models consider different seeding and accretion scenarios4,5,6,...
As both data-driven and phenotypically stratified analyses indicated TCA and associated pathways to be disrupted in disease, we performed a concerted investigation of the TCA cycle enzymes, including those that metabolize anaplerotic (replenishing TCA cycle intermediates) and cataplerotic (removing TCA cy...
Protein synthesis is a highly controlled process essential for cellular homeostasis, and its suppression under stress contributes to maintaining cellular energy balance3. The integrated stress response (ISR) is an integral arm of the unfolded protein response that reprograms translation under a broad rang...
Multimodal astrocyte–neuron communications govern brain circuitry assembly and function1. For example, through rapid glutamate release, astrocytes can control excitability, plasticity and synchronous activity2,3 of synaptic networks, while also contribu
We speak with Iain Ainsworth, founder of ‘The Aficionados’. Plus: Anja Charbonneau on her cat magazine ‘Catnip’, ‘Condé Nast Traveler’ annual Hot List and an interview with Indonesian news anchor Najwa Shihab. Play Download Share Copied! 26 Apr 2025 Lala Books, Climax Books, Go...
Quaternary landforms, sediments and soils not only have their own intrinsic value as part of nature, but also form the foundations of most habitats in terrestrial and marine environments (Kaskela et al., 2017; Lausch et al., 2019, Lausch et al., 2020; Lucatelli et al., 2020; Tukiainen...
J Balvin Gets Abducted by Aliens, Doja Cat Gyrates in Mud at Coachella Day Three Coachella 2024 was the year of the A-list guests. Across all three days, top stars made appearances either onstage or in the crowd to support their musician besties. Olivia Rodrigo joined No Doubt, Will Smith...
“He doesn’t need to keep the camera rolling all of the time. He has an innate feeling for when to shoot the animals.” Allan is no doubt a human who can form a relationship with a whale, polar bear, or orangutan in the same way other people might with a dog or a cat. “...
In addition, a set of curated genes relevant to T cell function or cell-type identification were included into the list of variable genes. UMAP embedding was performed using the first 50 principal components. Cell types were assigned to all cells based on canonical lineage marker expression. ...