Neurons receive thousands of inputs onto their dendritic arbour, where individual synapses undergo activity-dependent plasticity. Long-lasting changes in postsynaptic strengths correlate with changes in spine head volume. The magnitude and direction of s
The study aims to address future energy and water resource scarcity challenges using multisector river basin–energy system analysis. Effective bidirectional communication between energy dispatch and dam operations allows the multisector river basin and energy system simulation models to be accurate and ...
Somatic mutations are an inevitable component of ageing and the most important cause of cancer. The rates and types of somatic mutation vary across individuals, but relatively few inherited influences on mutation processes are known. We perform a gene-based rare variant association study with diverse...
This study aims to build an artificial intelligence (AI)-based inference model to predict the coefficient of performance (COP) for refrigeration equipment under various R404A refrigerant conditions. The proposed model, the evolutionary multivariate adaptive regression splines (EMARS), is a hybrid of ...
In other words, MIM does not account for the compression or abstraction of temporal inputs, whereas MRIL aims to describe how these processes may be executed in the brain and incorporates them into the model. Our results suggest such processes can even occur at the level of single cortical ...
This conservative approach aims to identify the strongest candidates underlying serpentine adaptation for further model-based inference of the sources of variation in the next section. We note that this approach discards population-specific (private) candidates and cases of distinct genetic architecture of...
The genetic analysis of potato is hampered by the complexity of tetrasomic inheritance. An ongoing effort aims to transform the clonally propagated tetraploid potato into a seed-propagated diploid crop, which would make genetic analyses much easier owing to disomic inheritance. Here, we construct a...
Across the globe, tree species are under high anthropogenic pressure. Risks of extinction are notably more severe for species with restricted ranges and distinct evolutionary histories. Here, we use a global dataset covering 41,835 species (65.1% of know
Here, we provide an overview of the programme currently underway in UK Biobank (UKB), the largest and most detailed imaging study to date. The UKB imaging enhancement aims to perform brain, cardiac and abdominal MRI, full body dual-energy X-ray absorptiometry (DXA) and a carotid ultrasound ...
Somatic mutations are an inevitable component of ageing and the most important cause of cancer. The rates and types of somatic mutation vary across individuals, but relatively few inherited influences on mutation processes are known. We perform a gene-based rare variant association study with diverse...