Nature 547, 94–98 (2017). Article CAS PubMed Central PubMed Google Scholar Dash, P. et al. Quantifiable predictive features define epitope-specific T cell receptor repertoires. Nature 547, 89–93 (2017). Article CAS PubMed Central PubMed Google Scholar Chronister, W. D. et al. TCR...
Paclitaxel is an anticancer therapeutic produced by the yew tree. Over the last two decades, a significant bottleneck in the reconstitution of early paclitaxel biosynthesis has been the propensity of heterologously expressed pathway cytochromes P450, inc
Recent advances in single-cell technologies have enabled high-throughput molecular profiling of cells across modalities and locations. Single-cell transcriptomics data can now be complemented by chromatin accessibility, surface protein expression, adapti
SGLT2is induce a metabolic shift towards ketogenesis, which is likely to account for sustained weight loss. The beneficial effects of GLP1RAs on the kidney are not solely explained by weight loss or improvement in glycaemic control. Several GLP1R dual or polyagonist agents are under evaluation w...
Dash, P. et al. Quantifiable predictive features define epitope-specific T cell receptor repertoires. Nature 547, 89–93 (2017). Article ADS CAS PubMed PubMed Central Google Scholar Bassez, A. et al. A single-cell map of intratumoral changes during anti-PD1 treatment of patients with brea...
(GNATs) using acetyl-CoA as a donor molecule for lysine acetylation5,6,7,8. These enzymes structurally resemble mammalian GNATs in their active site architecture5,7,9,10,11,12. Bacterial GNATs are classified into several different subgroups depending on the presence of additional C- and/or N...
Urban areas are the largest source of pollutants that directly or indirectly will end up in the air, soil, and water. It is paramount to find solutions to reduce the impact of pollution on climate change, ecosystem services, biodiversity loss, and human
Excitation spectra were recorded using emission at 550 nm, excitation from 380 to 535 nm in steps of 2 nm. Kinetics of l-2-HG binding by LHGFR were assessed by using SX-20 stopped-flow fluorimeter (Applied Photophysics, UK). Equal volumes of 1 μM purified LHGFR in 50 mM...
Covalent organic frameworks (COF), with rigid, highly ordered and tunable structures, can actively manipulate the synergy of entropic selectivity and enthalpic selectivity, holding great potential as next-generation membrane materials for ion separations
(GNATs) using acetyl-CoA as a donor molecule for lysine acetylation5,6,7,8. These enzymes structurally resemble mammalian GNATs in their active site architecture5,7,9,10,11,12. Bacterial GNATs are classified into several different subgroups depending on the presence of additional C- and/or N...