2023年9月6日,复旦大学卢智刚、罗敏和高海与中国科学院分子细胞科学卓越创新中心赵允团队利用CRISPR-Cas9技术筛选到在肿瘤模型小鼠PMN-MDSCs高表达的膜蛋白CD300ld。靶向敲除CD300ld通过抑制STAT3通路减少PMN-MDSCs的募集和免疫抑制功能,重塑肿瘤免疫微环境,发挥广谱抗肿瘤效果。 研究亮点 Highlight 1. 发现了一个新的...
et al. CD300ld on neutrophils is required for tumour-driven immune suppression. Nature 621, 830–839 (2023). https://doi.org/10.1038/s41586-023-06511-9 Download citation Received16 April 2022 Accepted01 August 2023 Published06 September 2023 Issue Date28 September 2023 DOIhttps://doi.org/...
Nature volume 621, pages 271–275 (2023)Cite this article 4172 Accesses 7 Citations 350 Altmetric Metrics details Abstract Powerful relativistic jets are one of the ubiquitous features of accreting black holes in all scales1,2,3. GRS 1915 + 105 is a well-known fast-spinning black-hole ...
Our model unveils intriguing dynamics in the relationship between the thickness and pore pressure of incoming plate sediments and the stress state of the overriding plate. By integrating the horizontal stress vertically within the overriding plate at a distance of 300 km from the trench, we could...
Article03 April 2023 The Bitter Taste Receptor TAS2R16 Achieves High Specificity and Accommodates Diverse Glycoside Ligands by using a Two-faced Binding Pocket ArticleOpen access10 August 2017 The appearance of bitter taste receptors — inspiration from structure, expression, function, and mechanism ...
621 Nature Trl Unit 86 Soddy Daisy, TN 37379 Property detail for 614 Nature Trl Unit 12 Soddy Daisy, TN 37379 Sold on January 8, 2025 $437,545 3bed 2bath 2,000sqft2,000 square feet 0.39acre lot0.39 acre lot 614 Nature Trl Unit 12 Soddy Daisy, TN 37379 Property detail for 579 ...
560 Hatch Trl, Soddy Daisy, TN 37379 $300,000 - - 2,621 43,560 548 Hatch Trl, Soddy Daisy, TN 37379 N/A 3 - 1,650 N/A 1018 Jonas Dr, Soddy Daisy, TN 37379 $210,000 - - 2,210 43,560 588 Nature Trl, Soddy Daisy, TN 37379 $333,000 4 - 3,284 N/A 598 Sir Carlo...
Nature 621, 577–585 (2023). Article ADS PubMed PubMed Central CAS Google Scholar Krok, A. C. et al. Intrinsic dopamine and acetylcholine dynamics in the striatum of mice. Nature 621, 543–549 (2023). Article ADS PubMed PubMed Central MATH CAS Google Scholar Jing, M. et al. An...
Nature volume 621, pages 188–195 (2023)Cite this article 28k Accesses 39 Citations 503 Altmetric Metrics details Abstract γδ T cells are potent anticancer effectors with the potential to target tumours broadly, independent of patient-specific neoantigens or human leukocyte antigen background1,2...
300, G665–675, (2011). Article CAS PubMed Google Scholar Wang, Y. C. et al. Intestinal cell type-specific communication networks underlie homeostasis and response to Western diet. J. Exp. Med. 220, e20221437 (2023). Hashizume-Takizawa, T., Kobayashi, R., Tsuzukibashi, O., Saito,...