2023年9月6日,复旦大学卢智刚、罗敏和高海与中国科学院分子细胞科学卓越创新中心赵允团队利用CRISPR-Cas9技术筛选到在肿瘤模型小鼠PMN-MDSCs高表达的膜蛋白CD300ld。靶向敲除CD300ld通过抑制STAT3通路减少PMN-MDSCs的募集和免疫抑制功能,重塑肿瘤免疫微环境,发挥广谱抗肿瘤效果。 研究亮点 Highlight 1. 发现了一个新的...
et al. CD300ld on neutrophils is required for tumour-driven immune suppression. Nature 621, 830–839 (2023). https://doi.org/10.1038/s41586-023-06511-9 Download citation Received16 April 2022 Accepted01 August 2023 Published06 September 2023 Issue Date28 September 2023 DOIhttps://doi.org/...
2023年9月6日,复旦大学卢智刚、罗敏和高海与中国科学院分子细胞科学卓越创新中心赵允团队利用CRISPR-Cas9技术筛选到在肿瘤模型小鼠PMN-MDSCs高表达的膜蛋白CD300ld。靶向敲除CD300ld通过抑制STAT3通路减少PMN-MDSCs的募集和免疫抑制功能,重塑肿瘤免疫微环境,发挥广谱抗肿瘤效果。 研究亮点 Highlight 1. 发现了一个新的...
in K562 cells. In total, 1.2 × 106K562 cells were electroporated in 100 μl of Amaxa solution (Lonza Nucleofector 2b, program T-016), with 300 ng of the 11.6-kb LSR plasmid, 869 ng of the 4.2-kb attB plasmid and 621 ng of the 3-kb attP plasmid...
Volume 621, pages 267–270, (2023) Cite this article Download PDF You have full access to this open access article From View current issue Submit your manuscript Joris Witstok, Irene Shivaei, Renske Smit, Roberto Maiolino, Stefano Carniani, Emma Curtis-Lake, Pierre Ferruit, ...
This work was supported by the National Key R&D Program of China (2022YFA1302701), the National Natural Science Foundation of China (32030056), the scientific project of Beijing Life Science Academy (2023300CA0090), the King Abdullah University of Science and Technology (KAUST) Office of ...
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Nature volume 621, pages 271–275 (2023)Cite this article 4120 Accesses 7 Citations 350 Altmetric Metrics details Abstract Powerful relativistic jets are one of the ubiquitous features of accreting black holes in all scales1,2,3. GRS 1915 + 105 is a well-known fast-spinning black-hole ...
Nature volume 621, pages 493–498 (2023)Cite this article 39k Accesses 103 Altmetric Metrics details Abstract Although high-transition-temperature (high-Tc) superconductivity in cuprates has been known for more than three decades, the underlying mechanism remains unknown1,2,3,4. Cuprates are the...