Elongin is a heterotrimeric elongation factor for RNA polymerase (Pol) II transcription that is conserved among metazoa. Here, we report three cryo-EM structures of human Elongin bound to transcribing Pol II. The structures show that Elongin subunit ELOA
B., Kundu, N. et al. Molecular mechanics underlying flat-to-round membrane budding in live secretory cells. Nat Commun 13, 3697 (2022).https://doi.org/10.1038/s41467-022-31286-4.IISTED XZ plane images of PHG(green) and dynamin-mTFP1 (red) showing dynamin puncta flanked and moved with...
Ross L. Levine Nature Reviews Cancer12,599–612 (2012)Cite this article 23kAccesses 18Altmetric Metrics Key Points Mutations in epigenetic modifiers account for new classes of mutant disease alleles that contribute to the pathogenesis of myeloid malignancies in addition to the classical class I genes...