Hypertension is a leading risk factor for disease burden worldwide. The kidneys, which have a high specific metabolic rate, play an essential role in the long-term regulation of arterial blood pressure. In this review, we discuss the emerging role of ren
a,bVolcano plots showing differentially abundant persulfidated proteins in heart (a) and plasma (b) from AL (n = 4 mice/group) versus DR (n = 5 mice/group) cystathionine γ-lyase (CGL) wildtype (WT) mice. The log2(Fold Change DR:AL) X-axis displays the average fold cha...
Recombinant adeno-associated viruses (rAAVs) have emerged as promising gene therapy vectors due to their proven efficacy and safety in clinical applications. In non-human primates (NHPs), rAAVs are administered via suprachoroidal injection at a higher do
The immune system is intimately involved in the pathophysiology of heart failure. However, it is currently underused as a therapeutic target in the clinical setting. Moreover, the development of novel immunomodulatory therapies and their investigation for the treatment of patients with heart failure are...
[61] Sheldrick T C, Barry T L, Dash B, Gan C SC, Millar I L, Barfod D N, Halton A M. Simultaneous and extensive removal of the east Asian lithospheric root. Sci Rep , 2020 , 10: 4128 CrossRef ADS Google Scholar [62] Shorttle O, Maclennan J. Compositional trends of Ic...
Organoid and spheroid technology provide valuable insights into developmental biology and oncology. Optical coherence tomography (OCT) is a label-free technique that has emerged as an excellent tool for monitoring the structure and function of these samp
A major drawback of single-cell ATAC-seq (scATAC-seq) is its sparsity, i.e., open chromatin regions with no reads due to loss of DNA material during the scATAC-seq protocol. Here, we propose scOpen, a computational method based on regularized non-negativ
To further demonstrate the prospect in complex patterning of IBFW, we fabricate a liquid film pattern making up the words “PKU COE” (Peking University College of Engineering) in Fig.1e. The word patterns are all drawn employing NPVE without physical masks. Throughout the patterning process, ...
N = 589 individuals for DCS, n = 899 individuals for GoDARTS, n = 1992 individuals for ANDIS validation, n = 1850 individuals for ACCELERATE validation. b Association between protein levels and incident diabetes. X-axis, odds ratio on a log2 scale. Data are presented as...
(negative control). Solid lines indicate staining of cells transfected with the wild-type (black) or mutant genes (red). A vertical dash line marks the threshold (CD59-gating) determined from the negative control. Shown is a representative result from three independent experiments. Data for all...