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the objective response rate for sorafenib in SHARP study is only 2%4, suggesting that most HCCs are intrinsically resistant to sorafenib. Recent studies suggest that epigenetics, transport processes, regulated cell death, and the tumor microenvironment are involved in the initiation and development of ...
了解人类对全球水文循环的影响程度对于地球淡水资源的可持续性至关重要1,2。然而,由于缺乏对世界池塘、湖泊和水库的水位观测,与自然变化相比,人类管理的(水库)地表水储存变化的量化受到限制3。因此,地表水体的全球储存变异性及其被人类改变的程度仍然未知。在这里,我们表明,地球61%的季节性地表水储存变化发生在人类管理...
在2007-2008年金融危机之后,中央交易对手 (central clearing counterparties,CCPs)的建立意味着交易者的许多双边合同单一机构(中央交易对手)重新安排。事实表明,中央清算通常会降低系统性风险[70-74],但也会增加对抵押品的需求[75],尤其是在有较多[72]中央交易对手的情况下。还有证据表明,对于清算成员中发生违约基金的...
2021年6月, Nature Reviews Physics 发表长文综述“金融网络的物理学”,探讨了统计物理学、网络科学和经济学的深刻联系。 研究领域:金融网络,金融传染,网络科学,统计物理学,信息论 Marco Bardoscia et al.| 作者 冯子健| 译者 张澳、梁金 | 审校 邓一雪| 编辑 论文题目: The physics of financial networks ...
2021年6月,Nature Reviews Physics 发表长文综述“金融网络的物理学”,探讨了统计物理学、网络科学和经济学的深刻联系。 研究领域:金融网络,金融传染,网络科学,统计物理学,信息论 Marco Bardoscia et al. | 作者 冯子健 | 译者 张澳、梁金 | 审校 邓一雪 | 编辑 论文题目: The physics of financial networks...
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Senescent cells accumulate throughout the body with advanced age, diseases and chronic conditions. They negatively impact health and function of multiple systems, including the central nervous system (CNS). Therapies that target senescent cells, broadly
Translational and clinical research Focus 26 January 2021 Sections Figures References Abstract Introduction Results Discussion Methods Data availability References Acknowledgements Author information Ethics declarations Peer review Additional information Supplementary information Source data Rights and permissions About...
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