all administered intravenously in 21-d cycles. Patients achieving a cCR and opting to proceed without cystectomy received single-agent nivolumab 240 mg intravenously every 2 weeks for eight doses. Patients with a cCR and forgoing immediate cystectomy then proceeded with surveillance using the fol...
To understand when and how RT emerges during development, we used single-cell Repli-seq5,19in preimplantation mouse embryos (Fig.1a,b). We collected 529 individual cells of which 53, 54, 50, 49, 34, 44 and 55 passed quality control for zygotes, 2-cell, 4-cell, 8-cell, 16-cell,...
Excessive fat deposition in obesity has a multifactorial aetiology, but is widely considered the result of disequilibrium between energy intake and expenditure. Despite specific public health policies and individual treatment efforts to combat the obesit
245. Basel Committee on Banking Supervision. Global systemically important banks: updated assessment methodology and the higher loss absorbency requirement. Bank for International Settlements https://www.bis.org/publ/bcbs255.pdf(2013). 246. Anand, K., Gai, P. & Marsili, M. Rollover risk, networ...
2010-2020 年 FDA 批准的药物。2010 年至 2020 年间,440 种创新药获 FDA 批准上市(补充表 1)。其中,35种创新药未提供临床开发开始日期:10种药物未提供研究性新药(IND)申请的原始提交日期,25种药物的初始临床开发发生在美国境外,且...
Non-Western science and knowledge marginalization began in ancient Greece [239]. It intensified during the Renaissance period—between the XIV and XVI centuries—when a few European nations were considered the home—and legitimate owners—of modern science, framed by the scientific revolution [240,241...
Shi, X. et al. Large-area display textiles integrated with functional systems. Nature 591, 240–245 (2021). Loke, G. et al. Digital electronics in fibres enable fabric-based machine-learning inference. Nat. Commun. 12, 3317 (2021). ...
2021年6月, nature reviews physics 发表长文综述“金融网络的物理学”,探讨了统计物理学、网络科学和经济学的深刻联系。 研究领域:金融网络,金融传染,网络科学,统计物理学,信息论 marco bardoscia et al. | 作者 冯子健 | 译者 张澳、梁金 | 审校 ...
Nature 591, 240–245 (2021). Article CAS PubMed Google Scholar Zhou, Z., Liu, T., Khan, A. U. & Liu, G. Block copolymer–based porous carbon fibers. Sci. Adv. 5, eaau6852 (2019). Article PubMed PubMed Central Google Scholar Cheng, K. C. et al. Templated nanofiber ...
Genet. 25, 240–245 (2017). Article PubMed Google Scholar Willer, C. J., Li, Y. & Abecasis, G. R. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26, 2190–2191 (2010). Article CAS PubMed PubMed Central Google Scholar Gen-ABEL project. ...