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Next, we assessed the feasibility of using BEs to generate antibody-discernible amino acid substitutions in D1-1, D2-1 and D2-2. BEs constitute a class of genome editors that is based on a catalytically impaired CRISPR–Cas nuclease fused to a deaminase. Cytosine BEs (CBEs) catalyse C to...
论文链接：https://www.nature.com/nature/volumes/582/issues/7810 邓旭课题组：http://www.ccsi....
582 ORGANIC LETTERS 583 ORGANIZATIONAL RESEARCH METHODS 584 EUROPEAN JOURNAL OF EPIDEMIOLOGY 585 Circulation-Heart Failure 586 mSystems 587 METABOLISM-CLINICAL AND EXPERIMENTAL 588 Tissue Engineering Part B-Reviews 589 CANCER LETTERS 590 CLINICAL NUCLEAR MEDICINE 591 ACM TRANSACTIONS ON GRAPHICS 592 IEEE ...
(导读 刘奇)消化道到大脑的机械力感受反馈可约束过量摄食,但肠道-大脑的交流通路和机制仍未解决。本研究表明小鼠表达强啡肽原基因的臂旁核中神经元(PBPdyn神经元)通过上消化道的机械力感受信号监测固液食物的摄入。PBPdyn神经元通过颅骨和脊髓通路连接到消化系统周围,抑制PBPdyn神经元群体导致小鼠过度消耗,该发现揭示了...
作者进一步开发了物理沉积+去合金化的新方法,在气体扩散电极上大面积制备了纳米多孔Cu-Al催化剂并精确调控其表面组分含量,实现在600 mA cm-2的高电流密度下,CO2到C2H480%的法拉第效率;通过改进电极结构,在保持150 mA cm-2的高电流密...
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