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与耐药性的发展形成鲜明对比的是抗生素的开发愈发缓慢,2015年初,美国东北大学Kim Lewis教授成功发现了近30年来的第一个新型抗生素teixobactin2。历时四年的不断探索,Kim Lewis教授团队再次发现一种新型抗生素——darobactin, 一种发光杆菌的代谢产物,含有7个氨基酸的短肽,可通过结合一个关键外膜蛋白bamA,选择性杀伤革...
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1. Ling, L. L. et al. A new antibiotic kills pathogens without detectable resistance.Nature517, 455–459 (2015). 2. Giltrap, A. M. et al. Total synthesis of teixobactin. Org. Lett. 18, 2788–2791 (2016). 3. P...