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followed by lifespan assays inC. elegans,bATP assay screening revealed 29 small-molecule candidates (5 µg/ ml) that inhibit cellular ATP levels by 5–10% (average plus SD) compared to DMSO solvent control after 15 min of incubation. 10 ...
Program in Bioinformatics, University of Toledo, 3100 Transverse Drive, Toledo, OH, 43614, USA Robert M Blumenthal Corresponding author Correspondence to Robert M Blumenthal. Additional information Competing interests The authors declare no competing interests. Authors’ contributions RB conceived the study...
We acknowledge support from the DFG (SFB 765 and SPP 1623), the Fonds der Chemischen Industrie, the Einstein Foundation and the Boehringer-Ingelheim Foundation (Plus 3 award). Author information Authors and Affiliations Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10...
Department of Mechanical, Aerospace and Biomedical Engineering, University of Tennessee, Knoxville, TN, 37996, USA Lijin Xia, Scott C Lenaghan, Mingjun Zhang, Zhili Zhang & Quanshui Li Corresponding author Correspondence to Mingjun Zhang. Additional information Competing interests The authors declare tha...
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(Schrödinger Inc, NY, USA). The structures were energy minimized with Chimera software50, and the new coordinates were used for docking calculations. Structures of the drugs rabeprazole and auranofin were obtained from the PubChem Compound Database (https://pubchem.ncbi.nlm.nih.gov)and ...
A 1 ml volume from each derived sample was injected into an Agilent 7890A/5975C GC-MS system (Agilent Technologies Inc., USA). An HP-5 MS fused silica capillary column (30 m 3 0.25 mm 3 0.25 mm, Agilent, USA) with a helium carrier gas flow rate of 1 ml/min was applied for ...