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Allogeneic donor-derived NK cells can be activated in vitro and infused into patients receiving stem cell transplants. We describe in this chapter the method to activate NK cells with cytokines and to ascertain their degree of activation.
Allogeneic donor-derived NK cells can be activated in vitro and infused into patients receiving stem cell transplants. We describe in this chapter the method to activate NK cells with cytokines and to ascertain their degree of activation.关键词:...
et al. Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56bright subset. Blood 121, 2669–2677 (2013). Article CAS PubMed PubMed Central Google Scholar Ferlazzo, G. et al. The abundant NK cells in human secondary lymphoid tissues require activation to express...
Growth and activation of natural killer cells ex vivo from children with neuroblastoma for adoptive cell therapy. We determined if large numbers of activated NK (aNK) cells can be grown ex vivo from peripheral blood mononuclear cells (PBMC) of children with high-... Yin,Liu,Hong-Wei,... -...
Another important benefit derived from EMRB’s activation of NK cells is that it enhances the body’s immune response to vaccines against both infections and cancers.56This is of special importance to older adults, whose vaccine responses are often weaker than desired. Finding effective ways to ...
such as some tumor cells and virus-infected cells28without a need for activation by other cell types or soluble molecules (as is the case for CD8+ cytolytic T lymphocytes). Activation of NK cells is regulated through activating and inhibitory cellsurfacereceptors.29The inhibitory receptors bind to...
The subject of endothelial regeneration and the ways in which stem and progenitor cells contribute to this process has promise in treating vascular diseases. As we will highlight in this review, some questions have been addressed but many more remain and need to be addressed before cell-based ...
augmented antimyeloma activity, but the overall response was significantly diminished by the contraction and reduced function of KIR2D-expressing cells.89Combination ofKIR blockadewith stimulatory cytokines, anti-TAA antibodies, or other agents reported to promote NK-cell activation such aslenalidomidecould...
Killer Ig-like receptor-mediated control of natural killer cell alloreactivity in haploidentical hematopoietic stem cell transplantation In a self-environment, they sense and kill target cells lacking major histocompatibility complex class I molecules and release various cytokines on activation... L Moretta...