Novel psychoactive substances (NPS) represent a broad class of drugs new to the illicit market that often allow passing drug-screening tests. They are characterized by a variety of structures, rapid transience on the drug scene and mostly unknown metabol
Department of Molecular and Cellular Pharmacology, Peking University School of Pharmaceutical Sciences, Beijing 100083, China Correspondence: Jian-Hui (Liang-liangjh@bjmu.edu.cn) Chinese Medicine 2023, 18(S2): A7 Background: Liang’s contextual-stress box (Liang’s Box) is designed and invented ...
2023, Nutrients Natural abundance carbon isotope ratio analysis and its application in the study of diet and metabolism 2021, Nutrition Reviews View all citing articles on Scopus This study was supported by Natural Sciences and Engineering Research Council of Canada Grant 482597. R.P.B. is supporte...
Sequencing grade trypsin Promega V5113 Bovine serum albumin AMRESCO 0332 Catalase Sigma-Aldrich C9322 Human recombinant HSP60 Sino Biological (http://www.sinobiological.com/) 11322-H20E Human recombinant HSP10 Sino Biological 11330-H07E Human recombinant MDH Sigma-Aldrich M1567-5KU ATP disodium salt...
The present work introduces a good prospect for the development of hierarchical catalysts with excellent catalytic performance in the methanol to aromatic hydrocarbons conversion (MTA) process. Hierarchical H-ZSM5 zeolites, with a tailored pore size and
, following the manufacturer's instructions. All SARS-CoV-2 infections were performed in a biosafety level 3 laboratory at the Institute of Biomedical Sciences, University of São Paulo, Brazil. The viral titers were determined by the qRT-PCR method using AgPath-ID™ One-Step RT-PCR Kit (...
As a result, three clinical trials evaluated (a) different combinations of 17a and the drug bevacizumab (BEV; Avastin®, Genentech Inc., South San Francisco, CA, USA), employed for the therapies of malignant glioma (WHO Grade IV) (NCT02330562) (b) individuals with newly diagnosed malignant...
Kijanska, M.; Kelm, J. In Vitro 3D Spheroids and Microtissues: ATP-Based Cell Viability and Toxicity Assays. InAssay Guidance Manual [Internet]; Eli Lilly& Company and the National Center for Advancing Translational Sciences: Bethesda, MD, USA, 2016; pp. 1–13. [Google Scholar] ...
研究了胞外ATP对胞内Ca2+信号的影响,初步探讨了其作用机制.实验表明:胞外ATP能够分别使大鼠胰腺β细胞和INS-1细胞内的游离Ca2+浓度显著升高,但2种细胞的钙信号来源不同.在大鼠胰腺β细胞中,胞外ATP主要通过动员胞内钙库释放而引起胞浆内Ca2+浓度显著增高;而在INS-1细胞内,胞外ATP主要通过引起胞外Ca2+内流而...
肌动蛋白细胞骨架磷酸化目的:研究ATP缺失时大鼠近端肾小管上皮细胞(NRK52E)肌动蛋白磷酸化水平的改变.方法:建立细胞的体外ATP缺失模型,用免疫印迹技术检测细胞内骨架组分及胞浆组分中肌动蛋白的分布变化;用二维电泳法分离并比较细胞内磷酸化和非磷酸化的肌动蛋白含量的改变;用免疫共沉淀法及免疫印...