In this Review, we explore natural product antibiotics that do more than simply inhibit an active site of an essential enzyme. We review these compounds to provide inspiration for the design of much-needed new antibacterial agents, and examine the complex mechanisms that have evolved to effectively...
Biochemistry Early Evaluation of Natural Products as Antibiotics and Chemical Biology Probes THE SCRIPPS RESEARCH INSTITUTE SchallenbergerMark AAntibacterial therapy places a strong selective pressure on the bacterial population that inevitably leads to the emergence of resistance. Therefore, there is a ...
In this Review, we explore natural product antibiotics that do more than simply inhibit an active site of an essential enzyme. We review these compounds to provide inspiration for the design of much-needed new antibacterial agents, and examine the complex mechanisms that have evolved to effectively...
the misuse of antibiotics also contributed to development of drug resistance, which might aggravate the bacteria infected disease. Thus, novel strategies other than antibiotics should be developed to combat the bacterial and biofilm formation. In last two decades, novel approaches in preventing...
Since then, syntheses of natural products have served as platforms for the demonstration of elegant strategies, for inventing new methodology ‘on the fly’ or to demonstrate the usefulness and scope of methods established with simpler molecules. We now add another aspect that we find fascinating, ...
We have also added a discussion of candidate drug entities currently in clinical trials as "warheads" and some very interesting preliminary reports on sources of novel antibiotics from Nature due to the absolute requirement for new agents to combat plasmid-borne resistance genes now in the general ...
natural productsA review of the use of natural products as starting points in the search for new pharmaceuticals, covering the broad areas of "Drugs affecting the centeral nervous system, " "Neuromuscular blocking drugs," "Anticancer drugs," "Marine sources," "Antibiotics," "Cardiovascular drugs,...
Screening strategies for discovery of antibacterial natural products Microbial-derived natural products have been a traditional source of antibiotics and antibiotic leads and continue to be effective sources of antibiotics t... SB Singh,K Young,L Miesel - 《Expert Rev Anti Infect Ther》 被引量: 66...
(2) Besides our focus on novel natural products, we also apply strategies to further develop either neglected drugs or widely used antibiotics for which development of resistance in the clinical setting is an issue: Antimycobacterial ... J Herrmann,Tadeja Lukei,A Kling,... - 《Curr Top Microb...
Antibiotics: past, present and future. Curr. Opin. Microbiol. 51, 72–80 (2019). Article CAS PubMed Google Scholar Rossiter, S. E., Fletcher, M. H. & Wuest, W. M. Natural products as platforms to overcome antibiotic resistance. Chem. Rev. 117, 12415–12474 (2017). Article CAS ...