Problem to be solved: to provide a method for producing natural killer (NK) cells and NK precursor cell populations.An isolated natural killer (NK) precursor cell populationHematopoietic stem cells or progenitor cellsFlt3L,TPOSCFIL-7G-CSFIL-6And cultured in a first medium containing GM-CSF(II...
As a promising alternative platform for cellular immunotherapy, natural killer cells (NK) have recently gained attention as an important type of innate immune regulatory cell. NK cells can rapidly kill multiple adjacent cancer cells through non-MHC-restr
NK-92 cells have a unique phenotype with the absence of most inhibitory killer cell immunoglobulin-like receptors and high expression of activating natural cytotoxicity receptors. In contrast to primary NK cells, they can be continuously expanded without changing their phenotype, facilitating the ...
their anti-tumor activity depends at least in part on the subsequent binding of natural killer (NK; a table of abbreviations is provided in Table Z, located after the Examples) cells to the Fc (constant) portion of the antibody with consequent destruction of the tumor cell via an antibody-d...
Natural killer (NK) cells are innate immune lymphocytes that recognize and rapidly lyse abnormal cells, including virally infected cells, allogeneic cells, and tumor cells, without antigen pre-sensitization or human leukocyte antigen (HLA) matching8,9. Although NK cells are universal killers in the...
Natural killer T cell lymphoma (NKTCL) is highly aggressive, with advanced stage patients poorly responding to intensive chemotherapy. To explore effective and safe treatment for newly diagnosed advanced stage NKTCL, we conducted a phase II study of anti
Everything you hear about fat in the diet, cholesterol, coronary artery disease and "clogged arteries" is focused on this problem -- blocked heart arteries and the heart attacks they cause are a leading killer in the United States. See What is a heart bypass operation? for additional details...
Lactiplantibacillus plantarum is a probiotic that was reported to modulate cytokine production by increasing TNF-α, IL-1β, IL-18, and IL-8, and reducing IL-6, a critical factor in immune dysregulation in COVID-19, thus enhancing the activity of natural killer cells [165]. In a ...
Normal aging is accompanied by escalating systemic inflammation. Yet the potential impact of immune homeostasis on neurogenesis and cognitive decline during brain aging have not been previously addressed. Here we report that natural killer (NK) cells of
Cytokine signaling via signal transducer and activator of transcription (STAT) proteins is crucial for optimal antiviral responses of natural killer (NK) cells. However, the pleiotropic effects of both cytokine and STAT signaling preclude the ability to precisely attribute molecular changes to specific ...