Natural killer cells, a specific lymphoid subpopulation comprised of large granular lymphocytes, appear to play an important role as a natural effector cell against primary and metastatic tumor cells. Rapid advances and widespread interest in this area of cell-mediated immunity promises to fully define...
H. T cell- and B cell-independent adaptive immunity mediated by natural killer cells. Nat. Immunol. 7, 507–516 (2006). The first report on antigen-specific NK cell responses. PubMed Google Scholar Paust, S. et al. Critical role for the chemokine receptor CXCR6 in NK cell-mediated ...
Natural killer (NK) cells have a dual role in human reproduction for maternal-fetal tolerance and protection from infection. During the ovarian cycle and pregnancy, peripheral NK (pNK) and uterine N
Natural killer cells in antitumour adoptive cell immunotherapy Article 25 July 2022 References Herberman, R. B., Nunn, M. E., Lavrin, D. H. & Asofsky, R. Effect of antibody to theta antigen on cell-mediated immunity induced in syngeneic mice by murine sarcoma virus. J. Natl Cancer ...
“Natural” killer cells in the mouse. II. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Characteristics of the killer cell. Eur. J. Immunol. 5, 117–121 (1975). Article CAS PubMed Google Scholar Vivier, E. et al. Innate or adaptive immunity? The example of natural...
In In Vitro Methods in Cell Mediated Immunity Against Tumors. B Bloom, J David (eds). New York, Academic Press, 1976, pp 423–428 Zarling JM, Eskra L, Borden EC, Horoszewicz J, Carter WA: Activation of human natural killer cells cytotoxic for human leukemia cells by purified ...
It turns out NK cells are even more important to the body than previously thought. Researchers from Brown University and McGill University now know that the cells also help keep T cells — major players in cell-mediated immunity — from over-responding. Such a balance helps T cells maintain ...
Learn about natural killer cells (NK cells), including natural killer cell development, receptors, and mediated killing and several tools to study NK cells.
While these cytokines play a role in many NKT cell-mediated immune responses, there is still further investigation required to determine whether they are required for the maintenance of transplant tolerance [17,20,21]. NKT cells are further divided into subsets of type I and type II NKT cells...
Natural killer cell mediated-antibody-dependent cellular cytotoxicity induces concentration dependent target cell death, granzyme production. Encoded Raji tumor cells (20K/well) were co-cultured with PBMCs (200K/well) from two separate donors. PBMCs were incubated with one of three anti-CD20 antibodie...