Mantovani et al., "Impaired intrahepatic natural killer cell cytotoxic function in chronic hepatitis C virus infection," Hepatology (Baltimore, Md), vol. Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels...
Natural killer cell degranulation capacity predicts early onset of the immune reconstitution inflammatory syndrome (IRIS) in HIV-infected patients with tuberculosis. Blood. 2012;119:3315–20.Pean P, et al. Natural killer cell degranulation capacity predicts early onset of the immune reconstitution ...
Natural killer (NK) cells are large lymphocytes characterized by the presence of numerous cytoplasmic granules containing many proteins (perforin, granzymes) withproteolytic activities. They lack antigen-specific receptors, such asIgorT cellreceptors, and are able to kill abnormal cells, such as some ...
Hence, antibody-coated cells can be recognized by CD16a expressing NK cells, leading to NK cell degranulation. Of interest, a functional polymorphism has been described, the F158V, the V variant being the one with the best affinity for the Fc moiety of IgG [92]. Lytic granules: NK cells...
. See Sect. "NK cell defects in NHL" for more information). A) NK cell functional defects include decreased expression of activating receptors, overexpression of suppressor receptors, decreased ADCC mechanisms, decreased IFN-γ production, and impaired degranulation capacity. B) Immunosuppressive cells...
Natural killer cells in peri-natally HIV-1-infected children exhibit less degranulation compared to HIV-1-exposed uninfected children and their expression of KIR2DL3, NKG2C, and NKp46 correlates with disease severity. J Immunol. 2007;179:3362–70.10.4049/jimmunol.179.5.3362Search in Google ...
the Spike protein-1 of SARS-CoV-2 can hinder the degranulation capacity of NK cells through the HLA-E/NKG2A pathway [121]. It is important to mention that there is an association between the emergence of adaptive-like NK cell expansions and severe/critical COVID-19. These expansions are ...
et al. Degranulation of natural killer cells following interaction with HIV-1-infected cells is hindered by downmodulation of NTB-A by Vpu. Cell Host Microbe 8, 397–409 (2010). CAS PubMed PubMed Central Google Scholar Ackerman, M. E. et al. Polyfunctional HIV-specific antibody responses...
As a promising alternative platform for cellular immunotherapy, natural killer cells (NK) have recently gained attention as an important type of innate immune regulatory cell. NK cells can rapidly kill multiple adjacent cancer cells through non-MHC-restr
Local inhibition of natural killer cell activity promotes the progressive growth of intraocular tumors. Invest Ophthalmol Vis Sci. 1997;38(6):1277–82. PubMed CAS Google Scholar Mao Y, van Hoef V, Zhang X, Wennerberg E, Lorent J, Witt K, et al. IL-15 activates mTOR and primes stress...