Truncated il-6, a natural inhibitor for iI-6 induced hematopietic cell activation?The interleukin-6 (IL-6) is a multifunctional cytokine that plays a role in the proliferation of haematopoietic progenitors, differentiation and growth of B, T cells or macrophages. A high level of its expression...
体内实验,通过人免疫缺陷病毒TAT中TAT肽的细胞穿透性(CPP)将大分子送到细胞中以测试它们的生物学功能。利用CPP将TM肽送进入细胞内使用免疫荧光观察(下图J)确定了TM肽对RLR诱导的I型IFN产生的影响。此外,向细胞中添加TM肽可促进RLR活化(下图K)并阻碍乳酸对IFN-b和IL-6产生的抑制作用(下图L)。
IL21 therapy combined with PD-1 and Tim-3 blockade provides enhanced NK cell antitumor activity against MHC class I-deficient tumors. Cancer Immunol. Res. 6, 685–695 (2018). Article CAS PubMed Google Scholar da Silva, I. P. et al. Reversal of NK-cell exhaustion in advanced melanoma ...
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6BIO: Wnt signaling activator (GSK3βinhibitor) CD: Circular dichroism CI: Combined index DOX: Doxorubicin DEX: Dexamethason EC50: The concentration for 50% of maximal effect Edwardsiella tarda: E. tarda Eupatorium perfoliatum: E. perfoliatum ...
Natural Killer Cell-Derived Exosomal miR-3607-3p Inhibits Pancreatic Cancer Progression by Targeting IL-26doi:10.2139/ssrn.3439550natural killer... H Sun,K Shi,K Qi,... - 《Social Science Electronic Publishing》 被引量: 0发表: 0年 Mammary epithelial cell-derived exosomal miR-155-inhibitor play...
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Inhibitor of DNA binding 2 IDO: indoleamine 2,3-dioxygenase ieILC1: Intraepithelial type 1 innate-like cell IFN-γ: Interferon γ IL: Interleukin ILC1s: Type 1 innate-like cells iNKT: Invariant natural killer T cell iPSC: induced pluripotent stem cells ITAM: Immunoreceptor tyrosine...
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Natural killer (NK) cells are lymphocytes with important roles in innate and adaptive immune responses to tumours and viral infection. However, in certain chronic diseases, including obesity and cancer, NK cell functional responses are impaired. Recently