[William Gull] endeavoured, above all things, to study the natural history of disease, uncomplicated by the action of unnecessary drugs, and he resented all useless interference with the course of nature. He would say of meddlesome poly-pharmacy—“Fools rush in, where angels fear to tread....
These chimpanzees are part of the larger Greater Mahale Ecosystem, meaning that additional nearby chimpanzee populations may be at risk for SIVcpz infection. Together, these studies show that SIVcpz is associated with an AIDS-like disease, that SIVcpz can but does not always negatively impact ...
What natural selection cannot do, is to modify the structure of one species, without giving it any advantage, for the good of another species; and though statements to this effect may be found in works of natural history, I cannot find one case which will bear investigation. A structure ...
Vision loss in NCL is thought to be due to cell death in both the visual cortex and in the retina. Cortical atrophy and neuronal cell loss is most pronounced in the occipital lobe of patients at end-stage disease1. The diseased retina has been observed to be no more than a glial scar ...
The English language-survey was adapted from two dedicated surveys: the adult natural history Rubinstein-Taybi syndrome study (Douzgou et al. [10]) and Sanford CoRDS Patient Registry [11] and modified with disease- and adult-specific questions for MALNS. The survey consisted of 115 questions and...
The English language-survey was adapted from two dedicated surveys: the adult natural history Rubinstein-Taybi syndrome study (Douzgou et al. [10]) and Sanford CoRDS Patient Registry [11] and modified with disease- and adult-specific questions for MALNS. The survey consisted of 115 questions and...
Central Illustration. Natural History of Subclinical Atrial Fibrillation: Histogram of Cumulative Duration of Atrial Fibrillation Evaluation of 590 patients continuously monitored during a median of 40.2 (37.6 to 42.4) months. The x-axis presents a logarithmic scale of cumulative AF duration, and the ...
Chronic kidney disease 1 (0.2) 25 (0.5) 230 (0.2) <.001 History of any cancer 151 (23.7) 707 (14.5) 14 159 (10.2) <.001 No. 638 4875 138 311 Medication use at baseline visit Antihypertensive medication 148 (23.0) 1110 (22.6) 26 751 (19.3) <.001 ...
(sensitized, allergized) by previous infection or vaccination; much of it results from body mechanisms that are poorly understood but differ from those responsible for the altered reactivity associated with the specific nature of acquired immunity; in general, innate immunity is nonspecific and is ...
The natural history of Alzheimer’s disease: Description of study cohort and accuracy of diagnosis. Arch. Neurol. 1994, 51, 585–594. [Google Scholar] [CrossRef] DementiaBank: Theoretical Rationale, Protocol, and Illustrative Analyses. Available online: https://pubs.asha.org/doi/10.1044/2022_AJ...