The effects of 5alpha-reductase inhibitors on the natural history, detection and grading of prostate cancer: current state of knowledge. J Urol 2005; 174:2098-104Andriole G, Bostwick D, Civantos F, et al. The effects of 5alpha- reductase inhibitors on the natural history, detection, and ...
THE EFFECTS OF 5α-REDUCTASE INHIBITORS ON THE NATURAL HISTORY, DETECTION AND GRADING OF PROSTATE CANCER: CURRENT STATE OF KNOWLEDGE 2005, The Journal of Urology more GERALD ANDRIOLE, DAVID BOSTWICK, FRANCISCO CIVANTOS, JONATHAN EPSTEIN, M. SCOTT LUCIA, JOHN McCONNELL, CLAUS G. ROEHRBORN THE EF...
redox couple is the predominant intracellular antioxidant that acts as a free radical scavenger and inhibitor of peroxidation [4]. Another critical system responsible for maintaining cellular redox homeostasis is the thioredoxin (Trx)/thioredoxin reductase (TrxR, encoded by TXNRD) dependent system, which...
摘要: Synthetic analogues of palmarumycin CP 1 were evaluated as new nanomolar to low-micromolar inhibitors of the thioredoxin–thioredoxin reductase redox system. Many derivatives showed significant growth inhibition against two breast cancer cell lines....
redox couple is the predominant intracellular antioxidant that acts as a free radical scavenger and inhibitor of peroxidation [4]. Another critical system responsible for maintaining cellular redox homeostasis is the thioredoxin (Trx)/thioredoxin reductase (TrxR, encoded by TXNRD) dependent system, ...
Structural insights into natural compounds as inhibitors of Fasciola gigantica thioredoxin glutathione reductasedoi:10.1002/jcb.26444drug targetmolecular dynamic simulationparasiteprincipal component analysisthioredoxin glutathione reductasevirtual screeningFascioliasis is caused by the helminth parasites of genus ...
Inhibitory effect of rhetsinine isolated from Evodia rutaecarpa on aldose reductase activity. Phytomedicine. 2009;16:258–61. Article CAS PubMed Google Scholar Su XL, Xu S, Shan Y, Yin M, Chen Y, Feng X, Wang QZ. Three new quinazolines from Evodia rutaecarpa and their biological activity...
it has been demonstrated that ferroptosis inhibitors, such as ferrostatin-1 and liproxstatin-1, can mitigate DP-mediated cell death in A549 cells. Overall, these findings support the hypothesis that DP can induce ferroptosis in the treatment of NSCLC [76]. The Qingrehuoxue Formula (QRHXF), a...
Treatment of diabetic complications with inhibitors of aldose reductase (AR) is biochemically attractive because the AR initiated accumulation of sorbitol, and its resulting pathology, only appears to be significant under nonphysiological conditions of hyperglycemia. A large variety of structurally diverse ...
Mulberry Diels–Alder-type adducts (MDAAs) are unique phenolic natural products biosynthetically derived from the intermolecular [4 + 2]-cycloaddition of dienophiles (mainly chalcones) and dehydroprenylphenol dienes, which are exclusively distributed in moraceous plants. A total of 166 MDAAs with...