作为一名年轻的企业家,他凭借自己的衍生公司Macomics获得了2019年创新奖。参考文献Cassetta L, Pollard JW. A timeline of tumour-associated macrophage biology. Nat Rev Cancer. 2023 Apr;23(4):238-257. doi: 10.1038/s41568-022-00547-1. Epub 2023 Feb 15. PMID: 36792751.>>>关于我们<<<...
在作者自己的研究中,发现 APR-246 增加了发炎因子(IFN)间的信号传导,促进了 CD4+ T 细胞浸润,并防止了 CD8+ T细胞在合成小鼠 TME 内耗竭。数据共同表明了突变p53 再激活在刺激免疫热 TME 中的作用,并支持将突变 p53再激活剂与免疫检查点抑制剂联合进行临床测试。
Department of Biochemistry and Molecular Genetics at the University of Alabama at Birmingham and O’Neal Comprehensive Cancer Center Birmingham, Alabama (US) University of Alabama at Birmingham Postdoc Researcher Research into the synthesis of near-infrared emitting/absorbing functional soft materials and ...
Analysis16 Nov 2023 Single-cell meta-analyses reveal responses of tumor-reactiveCXCL13+T cells to immune-checkpoint blockade Zhang and colleagues analyze single-cell data from patients treated with immunotherapy in five cancer types and find thatCXCL13-expressing subsets are implicated in response to ...
2024年4月11日,纽约大学格罗斯曼医学院Amanda W. Lund通讯在Nature reviews cancer发表“Lymphatic vessels in the age of cancer immunotherapy”的文章。 淋巴运输维持体内平衡健康,是免疫监测所必需的,然而淋巴生长通常与实体肿瘤的发展和传播有关。虽然肿瘤相关的淋巴重塑和生长最初被认为只是扩大了局部转移的被动途径...
由于肿瘤分子标志物定义的患者群体较小,预计这些药物的销售将受到限制。 参考文献: 1.Nat Rev Drug Discov. IF: 120.1Q12024 Feb 9. doi: 10.1038/d41573-024-00026-2IF: 120.1Q1.World J Gastrointest Surg.IF: 2.0Q3 2023 Apr 27;15(4):495-519....
Using a multi-omics approach, Wang et al. explored sex-specific and region-specific patterns of intestinal aging in non-human primates, identifying regulators with conserved functions inCaenorhabditiselegansintestinal aging, in colitis in mice and in patient colorectal cancer samples. ...
7、Nat Rev | 苏州系统医学研究所马瑜婷:应激背景下的癌症-免疫对话 8、Science | CXCL9:SPP1巨噬细胞极性确定是肿瘤微环境的一个简单而关键的特征 9、Cell Death Dis | 自噬引起铁死亡的正反馈循环 10、Cancer Cell | 演变中的肿瘤微环境:从癌症起始到转移生长 ...