Additionally, HCC cell lines (Hep3B, HepG2, and SMMC-7721) also exerted significantly decreased DUSP22 expression compared to the non-tumor cell line (Supplementary Fig. 24c and d). These results elucidated that DUSP22 downregulation might contribute to NAFLD-associated HCC development. Fig. 8...
Metformin, the first-line drug for T2DM, has been suggested to reduce risks for several types of cancers including HCC and protect against NASH-related HCC, as revealed by epidemical studies on humans and preclinical studies on animal models. This review focuses on the pathogenesis of NASH-...