Non-alcoholic fatty liver disease (NAFLD) has evolved as the most common form of chronic liver disease in children and has become a serious public health issue. As in adults, NAFLD in children is tightly associated with obesity, insulin resistance, and a number of obesity-related metabolic ...
liver disease-related hepatocellular carcinoma. Hepatol. Int. 10, S437 (2016). 5. Aby, E., Phan, J., Truong, E., Grotts, J. & Saab, S. Inadequate hepatocellular carcinoma screening in patients with nonalcoholic steatohepatitis cirrhosis. J. Clin. Gastroenterol. 53, 142–146 (2019). 6....
1.Siwaporn Chainuvati, Tongluk Teerasarntipan, Sombat Treeprasertsuk, et al. Risk of the Development of Acute-on-Chronic Liver Failure and Overall Mortality among Nonalcoholic Steatohepatitis-related Cirrhosis Patients with...
liver disease-related hepatocellular carcinoma. Hepatol. Int. 10, S437 (2016). 5. Aby, E., Phan, J., Truong, E., Grotts, J. & Saab, S. Inadequate hepatocellular carcinoma screening in patients with nonalcoholic steatohepatitis cirrhosis. J. Clin. Gastroenterol. 53, 142–146 (2019). 6....
约41%的NASH患者存在可检测的纤维化，而22%的晚期纤维化患者会发展为肝瘢痕，即肝硬化（cirrhosis）。最后，~2%的肝硬化患者可能在3年内发展为肝细胞癌(HCC)。（来源：Nature Reviews Endocrinology）非酒精性脂肪性肝炎（non-alcoholic steatohepatitis, NASH）是NAFLD的严重类型，被定义为5％以上的肝脏脂肪变性，合并...
6.Young, S. et al. Transarterial chemoembolization of hepatocellular carcinoma:propensity score matching study comparing survival and complications in patients withnonalcoholic steatohepatitis versus other causes cirrhosis. Cardiovasc. Interv. Radiol. 43,65–75 (2020). ...
所有治疗相关不良事件(treatment-related adverse events)均为轻度/中度,且没有明显的剂量关系。没有治疗相关严重不良事件,没有患者因任何不良事件(包括瘙痒)而停用TERN-101。与安慰剂组相比,5 mg和10 mg TERN-101治疗组未观察到LDL胆固醇产生变化,仅15 mg治疗组观察到显著的LDL变化。
(11) US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, Compensated cirrhosis related to non-alcoholic steatohepatitis: developing drugs for treatment guidance for industry...
NASH might get worse over time. Sometimes, it leads to serious scarring of the liver, called "cirrhosis." Cirrhosis can cause different symptoms, such as swelling in the legs, trouble breathing, or feeling tired. Do I need to follow up with my doctor?
[3] Loomba R, Abdelmalek MF, Armstrong MJ, Jara M, Kjær MS, Krarup N, Lawitz E, Ratziu V, Sanyal AJ, Schattenberg JM, Newsome PN; NN9931-4492 investigators. Semaglutide 2·4 mg once weekly in patients with non-alcoholic steatohepatitis-related cirrhosis: a randomised, placebo-contr...