85.Vuppalanchi R, Gould RJ, Wilson LA, et al.; Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN). Clinical significance of serum autoantibodies in patients with NAFLD: results from the nonalcoholic steat...
2月11日,吉利德科学(Gilead Sciences)宣布其非酒精性脂肪性肝炎(NASH)在研药物、ASK1抑制剂selonsertib(GS4997)在第一个Ⅲ期临床错过一级终点。 该STELLAR-4试验招募了877例NASH诱发代偿期肝硬化患者,比较2个剂量的selonsertib和安...
(5) Brunt EM, Kleiner DE, Wilson LA, Sanyal AJ, Neuschwander-Tetri BA; Nonalcoholic Steatohepatitis Clinical Research Network. Improvements in histologic features and diagnosis associated with improvement in fibrosis in nonalcoholic ...
86.Kowdley KV, Belt P, Wilson LA, et al.; NASH Clinical Research Network. Serum ferritin is an independent predictor of histologic severity and advanced fibrosis in patients with nonalcoholic fatty liver disease. Hepatology 2012;55:77–85...
NASHClinical Research NetworkRadiologic ModalityFuture ValidationPathologic DefinitionWe appreciate Yilmaz and colleagues' interest in our study describing NASH Diagnostics as a non-invasive diagnostic biomarker for nonalcoholic steatohepatitis ( NASH ) [ 1 ]. In their letter to the editor, these authors ...
NAS由Nonalcoholic·Steato·hepatitis·Clinical·Research·Network 提议(非专利文献2)。NAS与临床诊断相关, 将活性度设为8分满分, 认为5分以上时几乎都是NASH, 3、 4分时混有疑似NASH和非NASH, 低于3分时几乎都是非NASH。将脂肪化、 小叶内炎症、 气球样变性3 者分数化, 评价NAS的活动度。 以脂肪化和小叶...
Liver fibrosis was assessed by Sirius red staining and was classified into 7 stages according to the NASH Clinical Research Network Scoring System Definition and Scores as follows: F0: no fibrosis, F1a: mild zone 3 sinusoidal fibrosis, F1b: moderated zone 3 sinusoidal fibrosis, F1c: peri-...
美国非酒精性脂肪性肝炎临床研究网络病理学会(the Pathology Committee of the NASH Clinical Research Network, NASH-CRN)在设计和验证NAFLD的组织学评分系统时,将... 张洪锡 - 《浙江大学》 被引量: 0发表: 2012年 跟踪非酒精性...
the contextual detection of steatosis, ballooning and lobular inflammation; NAFLD activity score (NAS) was calculated as the sum of scores for steatosis, lobular inflammation, and ballooning [25]; fibrosis was quantified on the basis of the NASH Clinical Research Network Scoring System Definition [...
The objectives of this review were twofold: a) to identify the humanistic burden of disease and impairment of HRQoL in patients with diagnosed NASH and compensated cirrhosis expressed histologically as fibrosis stage F4 based on NASH Clinical Research Network categorisation9 from the perspective of ...