doi:10.1007/s10548-025-01114-1NarcolepsySpectral analysisEEG microstatesPolysomnographyMultiple sleep latency testEpworth sleepiness scaleThe primary distinction between narcolepsy type 1 (NT1) and narcolepsy type 2 (NT2) is the presence or absence of cataplexy, which is commonly determined through ...
It has been shown that narcolepsy, a chronic and disabling disease, starts in childhood and adolescence rather than adulthood. The International Classification of Sleep Disorder (ICSD-3) classifies narcolepsy into Type 1 (narcolepsy with cataplexy) and Type 2 (narcolepsy without cataplexy). There ...
Narcolepsy type 1 (NT1) and type 2 (NT2) are two rare neurological diseases, classified as central disorders of hypersomnolence. The pathophysiology of NT1
Studies conducted on humans3,4found that those who received orexin receptors through an IV had an improvement in narcolepsy type 1 and 2 symptoms of sleepiness. A randomized, phase 2, placebo-controlled trial of TAK-994 published in theNew England Journal of Medicine5in 2023 needed to be term...
1 Introduction Narcolepsy is defined as a sleep disorder characterized by irresistible episodes of sleep with short duration, cataplexy, and hypnagogic and hypnopompic hallucinations. This disorder has been categorized into two types (type 1 and type 2), based on the presence of cataplexy, which...
“narcolepsy” and never mentions “type 1” or “cataplexy” at all. In 2008, saying “type 1” or “type 2” was not typical as that’s been a more recent development in terminology, so it’s not too surprising that the 2021 Disney+ series updated his condition name to “type 1 ...
Takeda will present additional data from the Phase 2 trials and long-term extension (LTE) study of TAK-861 in narcolepsy type 1 (NT1) and narcolepsy type 2 (NT2) at Sleep Europe 2024, the 27th Congress of the European Sleep Research Society (ESRS), bei
1 or both of the following: Low levels of orexin/hypocretin in CSF Cataplexy and MSLT ≤ 8 minutes Narcolepsytype 2Type 2Spinal Muscular Atrophy: All criteria must bemetPreoperative Care. Daily periods of irrepressible need tosleepSleepA readily reversible suspension of sensorimotor interaction with...
Narcolepsy type 1 (NT1) is a unique neurological sleep disorder caused by the loss of neurons producing orexin (OREX) (also called hypocretin) [1,2]. Since their discovery, OREX neurons have been involved in important and diverse physiological functions such as sleep-wake regulation, reward/addi...
Two subtypes of narcolepsy have been described (narcolepsy type 1 and narcolepsy type 2), both of which have similar clinical profiles, except for the presence of cataplexy, which occurs only in patients with narcolepsy type 1. The pathogenesis of narcolepsy type 1 is hypothesized to be the ...