Usual Adult and Pediatric Dose for Opioid Overdose: Administer 1 spray intranasally into 1 nostril If desired response is not achieved after 2 or 3 minutes, give a second dose from a new nasal spray device, intranasally into alternate nostrils; additional doses may be administered every 2 to...
The duration of action is dependent upon the dose and route of administration of naloxone hydrochloride. 12.3 Pharmacokinetics In a pharmacokinetic study in 30 healthy adult subjects, the relative bioavailability (BA) of one nasal spray in one nostril, consisting of a 2 mg total dose (0.1 mL ...