Additionally, we present an enzymatic inhibition assay in nanowells to anticipate further applications, such as the high-throughput screening of drug candidates or the identification of novel enzymes for biotechnology. 展开 关键词: Bisphosphonate Care gap Diagnosis Fractures Males Osteoporosis ...
Gather wisdom to overcome barriers: Well-designed nano-drug delivery systems for treating gliomasdoi:10.1016/j.apsb.2021.08.013Jiwei CuiYuanxin XuHaiyan TuHuacong ZhaoRuoning WangActa Pharmaceutica Sinica B
In the field of drug delivery, for example, the effectiveness of a micellar drug carrier is determined by how well it can reach the targeted tissue or diseased areas. Despite having a simple criterion, many obstacles hinder the drug delivery efficiency and thus complicate the design of a ...
This is because that a lot of polymers such as PEG and dextran are biocompatible and practical for biomedical applications in drug delivery and tissue engineering. In our previous work, a dextran-based nanogel with CY7 labeling was applicable for lymph node fluorescence imaging [9]. However, ...
The preparation method comprises the following steps: preparing an albumin-glucan covalent complex by utilizing Maillard reaction; dissolving the albumin-glucan covalent complex in an aqueous solution to obtain one solution; dissolving or dispersing the hydrophobic drug in soybean oil to obtain one ...
The folic acid modified sulfobetaine-chitosan nano-granule provided by the invention has good biocompatibility and biodegradability and strong protein resistance ability; besides, due to the introduction of the folic acid grafting, the chemotherapeutic drug coated in the sulfobetaine-chitosan nano-granule ...
An antagonist of the A2A adenosine receptor, a G-protein-coupled receptor that is a drug target for neurodegenerative conditions, was displayed in 35 different multivalent configurations, and binding to A2A was determined. A theoretical model based on statistical mechanics was developed to interpret ...
Microwell plates are standard elements in any biotechnological system dealing with high throughput screening or drug discovery. Progressing from the current standards, we have investigated the microfabrication of higher density well plates with respect to an optimized well geometry. This included the ...
The quantification of protein provides a crucial perspective of pathology, drug treatment, and understanding of the disease. Label-free electronic affinity-based immunosensing is an attractive candidate as a platform technology for analyzing biomarkers due to the ease of miniaturization and the minimal ...
Saponin micelles, acts as a carrier medium of a drug ingredient, conventional drug carrier, it can be replaced, for example, pharmaceutical solubilizing agents or polymeric micelles, which has a high safety, are very good. Pharmaceutical ingredient, drug circulation time in the blood and to ...