Biological assays used to assess the potential toxicity of nanoparticles, from cell viability to mutations are described in this section, and designed specifically for readers who may not be too familiar with biological assay protocols. An overview of graphene and graphene oxide toxicity in cell and...
Liao et al [140] found that the toxicity of graphene and graphene oxide depended on whether or not aggregation occurred and on the mode of interaction with cells (i.e., suspension versus adherent cell types). Ekstrand-Hammarström et al [141] determined that crystal structure, surface area...
Nanocarriers represent an attractive means of drug delivery, but their biosafety must be established before their use in clinical research. Objectives Four kinds of amphiphilic polymeric (PEG-PG-PCL, PEEP-PCL, PEG-PCL and PEG-DSPE) micelles with similar hydrophilic or hydrophobic structure were prepa...
Meanwhile, recent theoretical studies have also revealed graphene's (including graphene oxide) influence on the integrity of cell membranes27–30, as well as protein structures23,25. Based on these findings from both experiment and theory on the fundamental mechanisms, various strategies have been ...
The unique physicochemical characteristics of nanoparticles have recently gained increasing attention in a diverse set of applications, particularly in the
Given their small size, NPs have larger structures in comparison with their counterparts. This distinct property allows their possible applications in many fields such as biosensors, nanomedicine, and bionanotechnology [4]. The intrinsic properties of metal NPs such as zinc oxide (ZnO), TiO2, and ...
Specific nanotoxicity of graphene oxide during zebrafish embryogenesis.. Chen Y,Hu X,Sun J et al. Nanotoxicology . 2015Y. Chen, X. Hu, J. Sun, Q. Zhou, Specific nanotoxicity of graphene oxide during zebrafish embryogenesis, Nanotoxicology 10 (2016) 42-52....
Graphene oxide (GO) has shown great potential forXiangangNankaiChenNankaiYumingNankaiSunNankaiJingNankaiZhouNankaiQixingNankaiNanotoxicologySpecific nanotoxicity of graphene oxide during zebrafish embryogenesis.. Chen Y,Hu X,Sun J et al. Nanotoxicology . 2015...
Graphene oxide (GO) is the most extensively studied two-dimensional material and has many potential applications in biomedicine, biotechnologies, and environmental technologies. However, its toxicological effects on aquatic organisms have not been properly investigated. Here, we compare the toxicity of ...
Our results point out implications for in vitro studies of graphene oxide materials concerning the effective dose delivered to cells and corona bioactivity. Finally, we demonstrated the importance of integrating conventional and modern techniques thoroughly to understand the GO-FBS complexes towards more ...