This has led to the identification of a series of oncogenic alterations that may serve as potential targets for drug development [17]. To date, several therapies targeting tyrosine kinase inhibitors (TKIs) have been established as first-line treatment in the clinic, such as TKI rearrangements for...
Glycofullerenes as non-receptor tyrosine kinase inhibitors- towards better nanotherapeutics for pancreatic cancer treatment Maciej Serda ,Katarzyna Malarz &Steven A. Curley Browse broader subjects Nanoscience and technology Browse narrower subjects Diagnostic devices ...
It should be highlighted that the resistance observed in EGFR tyrosine kinase inhibitors (TKIs) significantly contributed to insufficient anti-tumor efficacy. To address it, Yang et al. designed a pulmonary microsphere system, capable of co-delivering afatinib (AFT) and paclitaxel (PTX), denoted as...
Introduction of tyrosine kinase inhibitors for chronic myeloid leukemia treatment is associated to a 63% probability of maintaining a complete cytogenetic response, meaning that over 30% patients require an alternative methodology to overcome resistance, tolerance or side-effects. Considering the potential ...
a tyrosine kinase inhibitor [46]. Histone deacetylase (HDAC) inhibitors [47] and proteasome inhibitors (PI) may also act as autophagy inducers: Bortezomib, a PI used in the treatment of hematological malignancies, increases early formation of autophagosomes and LC3-II expression in prostate cancer...
allowing the delineation and definition of specific cancer subtypes and the identification of patient-specific biomarkers which advances personalized-targeted therapy. To date, there has been some success in precision therapy, particularly in the use of tyrosine kinase inhibitors such as imatinib, gefitini...
Accordingly, MMPs have been investigated for preventing and treating tumors; however, the delivery of MMP inhibitors has been challenging due to poor specificity. Recent studies have shown the use of NPs with potential MMP inhibitors to control metastasis in cancer therapy [138, 139]. For example...
Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4–and spleen tyrosine kinase–dependent activation of NADPH oxidase 2 Circ. Res., 104 (2) (2009), pp. 210-218 Google Scholar Bagwe et al., 2006 R.P. Bagwe, L.R. ...
obtained positive results utilizing a combination of nivolumab (PD-1 inhibitors) and AZA treatment to treat patients with refractory AML whose expression levels of PD-1 and PD-L1 increased constantly [19]. Other clinical studies have demonstrated that nivolumab combined with ibrutinib (BTK inhibitors...
Basically, the critical step of COVID-19 pathogenesis is SARS-CoV-2 intracellular entry through binding of S protein to angiotensin-converting enzyme (ACE) surface receptors that are specific receptors facilitating SARS-CoV-2 invasion of the host and then endosomal encapsulation and eventually the ...