However, its limited water solubility and sensitivity to light restrict its therapeutic applications. In recent years, researchers have been exploring ways to enhance the properties of curcumin. In the current investigation, curcumin was transformed into its nanoform by utilizingd-glucose in an aqueous...
Nanoparticle-based drug delivery approaches have the potential for rendering hydrophobic agents like curcumin dispersible in aqueous media, thus circumventing the pitfalls of poor solubility. Results We have synthesized polymeric nanoparticle encapsulated formulation of curcumin – nanocurcumin – utilizing the...
Nevertheless, widespread clinical application of this relatively efficacious agent in cancer and other diseases has been limited due to poor aqueous solubility, and consequently, minimal systemic bioavailability. Nanoparticle-based drug delivery approaches have the potential for rendering hydrophobic agents ...
The results presented indicate that incorporating curcumin into NDs overcomes the poor water solubility of this bioactive molecule. The particles generated are nanoscale, disk-shaped complexes of curcumin, DMPC, and apoA-I. As such, these data extend previous studies of NDs as a drug delivery vehic...
However, its application in the food and medical industry is greatly limited by its poor water solubility, physicochemical instability and inadequate bioavailability. Nanoliposome encapsulation could significantly enhance the solubility and stability of curcumin. Curcumin nanoliposomes exhibited good ...
We hypothesized that curcumin could be loaded into a biomimetic vehicle of electrospun gelatin nanofibers to enhance its solubility and availability and that these mats can be used to improve acute wound-healing processesin vitroandin vivo.
[13,15,18]. However, despite its promising properties, its clinical use has been constrained because of its poor water solubility (0.125 mg/L), poor bioavailability, severe metabolism, degradation, and quick excretion [15,16,17,18,19]. To circumvent these restrictions, numerous techniques have...
Curcumin-drug/or nanoparticle conjugates to target folate receptor in the cancer treatment Curcumin has been investigated to treat various conditions, including cancer, but its therapeutic applications are restricted by its poor water solubility and a lack of target selectivity. Therefore, it is imperati...
specifically in cancer, because of the better bioavailability and solubility of nanocurcumin when compared to natural curcumin. This review deals with the various applications of curcumin nanoparticles in cancer therapy and broadly tries to understand how it affect the immunological status of the cancer...
Nevertheless, the clinical application of curcumin is greatly restricted because of its low water solubility, poor oral absorption, and rapid metabolism. These issues have led to the development of curcumin nanoformulations to overcome the limitations of the compound. Nanotechnology-based delivery systems...