研究团队在小鼠和猴子中验证了NanoCas的实力: 肝脏实验:单针注射AAV-NanoCas,成功敲除胆固醇相关基因Pcsk9,小鼠血清有害蛋白近乎清零(图3); 肌肉实验:在模拟DMD的小鼠中,NanoCas精准修复抗肌萎缩蛋白基因,肌肉编辑效率达40%;更厉害的是,猴子肌肉单针注射8周后,编辑效率稳定在30%以上(图4),而传统工具SaCas9仅3%...
这项工作发表在 bioRxiv 上，预印本标题为“使用超紧凑核酸酶 NanoCas 对非人灵长类动物骨骼肌进行单 AAV CRISPR 编辑”。NanoCas 是一种新型 Cas 酶（大约是 Cas9 的三分之一大小），可以容纳在单个 AAV 载体中，同时为额外的有效载荷（如调节元件、向导 RNA 或非双链断裂编辑机制）留出空间。这可用于逆转...
Here we develop an integrated nano Cas12a sensor (InCasor) and show its utility for efficient imaging of mtDNA mutations in live cells and tumor-bearing mouse models. We co-deliver Cas12a/crRNA, fluorophore-quencher reporters and Mg2+ into mitochondria. This process enables the activation of ...
764-85-2 中文名称:壬酰氯 中文别名:正壬酰氯 英文名称:n-Nonanoyl Chloride 英文别名:Chlorure de nonanoyle; Nonanoic acid chloride; Nonanoyl Chloride; Nonanoylchlorid; PELARGONOYL CHLORIDE CAS号:764-85-2 EINECS号:212-131-2 分子式:C9H17ClO...
Here we develop an integrated nano Cas12a sensor (InCasor) and show its utility for efficient imaging of mtDNA mutations in live cells and tumor-bearing mouse models. We co-deliver Cas12a/crRNA, fluorophore-quencher reporters and Mginto mitochondria. This process enables the activation of Cas12a...
[Hexyl nonanoate]化源网提供Hexyl nonanoateCAS号37165-63-2,Hexyl nonanoateMSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询Hexyl nonanoate上化源网,专业又轻松。
CAS:516-55-2 MF:C21H34O2 MW:318.49 EINECS:208-224-2 Product Categories:Steroids Mol File:516-55-2.mol ALLOPREGNANOLONE Chemical Properties Melting point200℃ alphaD27 +91.2° (c = 0.4 in ethanol) Boiling point431.2±18.0 °C(Predicted) ...
Alloepipregnanolone structure Common Name Alloepipregnanolone CAS Number 516-55-2 Molecular Weight 318.49300 Density 1.053g/cm3 Boiling Point 431.2ºC at 760mmHg Molecular Formula C21H34O2 Melting Point 200℃ MSDS N/A Flash Point 183.9ºC ...
中文别名:434-360-9; 壬酸、2-磺酸酯钠盐(1:1); 2-(壬酰氧基)苯磺酸钠; WSQR BOV8 英文名称:sodium 2-(nonanoyloxy)benzenesulfonate 英文别名: 434-360-9; Nonanoic acid, 2-sulfophenyl ester, sodium salt (1:1); Sodium 2-(nonanoyloxy)benzenesulfonate; WSQR BOV8 & & Na salt CAS号:911...
CAS编号:126-53-4 包装规格:1g 别名:Tripelargonin; 1,3-di(nonanoyloxy)propan-2-yl nonanoate 英文名称:Trinonanoin 品牌:Mitachieve 分子式:C30H56O6 货号:MIT-33-0900-13 产地:欧美 纯度:>99% 是否进口:是 关于产品“Trinonanoin;CAS:126-53-4”的详情 ...