临床前测量方法通常具有破坏性,需要解剖,且药物生物分布量化所需的终点分析(end point analysis)需要在每个时间点处死多个动物,因此亟需快速、简便的测量方法。 有严重剂量限制性毒性的一类癌症药物是蒽环类药物(anthracyclines),包括柔红霉素(daunorubicin)、多柔比星(doxorubicin,Dox)、表柔比星(epirubicin)、伊达比星(i...
the stability of nanomicelles was investigated,which included dilution stability and storage stability.The results showed that P_(5k)SSLV-DOX nanomicelle had good dilution stability and storage stability at 4℃.The preparation method of P_(5k)SSLV-DOX nanomicelle with thinfilm hydration method ...
After being selectively retained in tumor tissues and endocytosed by tumor cells, the NLs disassemble in the presence of overexpressed glutathione (GSH) to release Fe3+-DOX nanocomplexes which then start to emit strong MR signal, whereby reporting the success and kinetics of cellular uptake of ...
Herein, smart nanodrug particles with reduction﹕ensitive and active tumor‐targeting ability are constructed based on the nanoprecipitation of glucosamineゞrafted pluronic L61 (GA㎜61) and disulphide﹍inked doxorubicin dimer (DOXSSDOX) to overcome tumor multidrug resistance (MDR). These nanoparticles ...
The hybrid nanosystem was produced by film hydration, and doxorubicin (DOX) was encapsulated in this system using the ammonium sulfate gradient method. The characterization of this hybrid nanosystem revealed a mean diameter of 140.20 ± 2.70 nm, a polydispersity index of 0.102 ± 0.033, an ...
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最后是多孔膜,将纳米管溶液热封于其中。体外剂量反应评估发现,多柔比星浓度高于5μM引发红移,但强度没有淬灭到其他材料的程度,某些纳米管手性产生的亮度高于基线(引入Dox前)。在全血清体外测试封装了DNA-纳米管的膜时,发现类似现象,但最大淬灭发生在50μM而不是5μM,符合血清中敏感性降低的结论。
(d)血清中5种纳米管手性的发生强度变化随Dox浓度的变化。 淬灭机理研究方面,缓冲液条件下添加多柔比星可见DNA-纳米管复合物发生聚集,用缺乏金属纳米管的单壁碳纳米管制剂实验也发生聚集,因此聚集可能不是猝灭的原因。随后评估多柔比星是否通过与吸附核苷酸碱基的竞争相互作用来取代纳米管表面的DNA。但荧光标记的DNA-...
were designed by conjugating doxorubicin (DOX) onto the hydrazine-functionalized crosslinked carbon quantum dots (CQDs)/polyethylene glycol bisacrylate (PEGBA) (C-CQDPEGBA-Hy) nanosponges via an acid-labile imine bond for the tumor intracellular real-time imaging and pH-triggered DOX release. The...